| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30069936 | HIV | ENSG00000184156.18 | protein_coding | KCNQ3 | No | No | 3786 | O43525 |
| TVIS30069937 | HIV | ENSG00000184156.18 | protein_coding | KCNQ3 | No | No | 3786 | O43525 |
| TVIS30069938 | HIV | ENSG00000184156.18 | protein_coding | KCNQ3 | No | No | 3786 | O43525 |
| TVIS20045044 | HPV | ENSG00000184156.18 | protein_coding | KCNQ3 | No | No | 3786 | O43525 |
| TVIS20062858 | HPV | ENSG00000184156.18 | protein_coding | KCNQ3 | No | No | 3786 | O43525 |
| TVIS20062392 | HPV | ENSG00000184156.18 | protein_coding | KCNQ3 | No | No | 3786 | O43525 |
| TVIS20062508 | HPV | ENSG00000184156.18 | protein_coding | KCNQ3 | No | No | 3786 | O43525 |
| TVIS20047015 | HPV | ENSG00000184156.18 | protein_coding | KCNQ3 | No | No | 3786 | O43525 |
| TVIS44016880 | HTLV-1 | ENSG00000184156.18 | protein_coding | KCNQ3 | No | No | 3786 | O43525 |
| TVIS44046016 | HTLV-1 | ENSG00000184156.18 | protein_coding | KCNQ3 | No | No | 3786 | O43525 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | KCNQ3 |
|---|---|
| DrugBank ID | DB04953 |
| Drug Name | Ezogabine |
| Target ID | BE0002398 |
| UniProt ID | O43525 |
| Regulation Type | |
| PubMed IDs | 17184917; 17456683; 10908292; 10953053 |
| Citations | Hirano K, Kuratani K, Fujiyoshi M, Tashiro N, Hayashi E, Kinoshita M: Kv7.2-7.5 voltage-gated potassium channel (KCNQ2-5) opener, retigabine, reduces capsaicin-induced visceral pain in mice. Neurosci Lett. 2007 Feb 14;413(2):159-62. Epub 2006 Dec 20.@@Punke MA, Friederich P: Amitriptyline is a potent blocker of human Kv1.1 and Kv7.2/7.3 channels. Anesth Analg. 2007 May;104(5):1256-64, tables of contents.@@Main MJ, Cryan JE, Dupere JR, Cox B, Clare JJ, Burbidge SA: Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine. Mol Pharmacol. 2000 Aug;58(2):253-62.@@Wickenden AD, Yu W, Zou A, Jegla T, Wagoner PK: Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels. Mol Pharmacol. 2000 Sep;58(3):591-600. |
| Groups | Approved; Investigational |
| Direct Classification | Phenylbenzamines |
| SMILES | CCOC(=O)NC1=C(N)C=C(NCC2=CC=C(F)C=C2)C=C1 |
| Pathways | |
| PharmGKB | PA144997862 |
| ChEMBL | CHEMBL41355 |
