| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20037785 | HPV | ENSG00000060982.15 | protein_coding | BCAT1 | No | No | 586 | P54687 |
| TVIS20050357 | HPV | ENSG00000060982.15 | protein_coding | BCAT1 | No | No | 586 | P54687 |
| TVIS44008986 | HTLV-1 | ENSG00000060982.15 | protein_coding | BCAT1 | No | No | 586 | P54687 |
| TVIS44012177 | HTLV-1 | ENSG00000060982.15 | protein_coding | BCAT1 | No | No | 586 | P54687 |
| TVIS44002980 | HTLV-1 | ENSG00000060982.15 | protein_coding | BCAT1 | No | No | 586 | P54687 |
| TVIS44013305 | HTLV-1 | ENSG00000060982.15 | protein_coding | BCAT1 | No | No | 586 | P54687 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | BCAT1 |
|---|---|
| DrugBank ID | DB00167 |
| Drug Name | Isoleucine |
| Target ID | BE0000517 |
| UniProt ID | P54687 |
| Regulation Type | |
| PubMed IDs | 12667063; 17554170; 15667998; 14962140; 12147502 |
| Citations | Goto M, Miyahara I, Hayashi H, Kagamiyama H, Hirotsu K: Crystal structures of branched-chain amino acid aminotransferase complexed with glutamate and glutarate: true reaction intermediate and double substrate recognition of the enzyme. Biochemistry. 2003 Apr 8;42(13):3725-33.@@Chen CD, Huang TF, Lin CH, Guan HH, Hsieh YC, Lin YH, Huang YC, Liu MY, Chang WC, Chen CJ: Purification, crystallization and preliminary X-ray crystallographic analysis of branched-chain aminotransferase from Deinococcus radiodurans. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jun 1;63(Pt 6):492-4. Epub 2007 May 5.@@Beck HC: Branched-chain fatty acid biosynthesis in a branched-chain amino acid aminotransferase mutant of Staphylococcus carnosus. FEMS Microbiol Lett. 2005 Feb 1;243(1):37-44.@@Thage BV, Rattray FP, Laustsen MW, Ardo Y, Barkholt V, Houlberg U: Purification and characterization of a branched-chain amino acid aminotransferase from Lactobacillus paracasei subsp. paracasei CHCC 2115. J Appl Microbiol. 2004;96(3):593-602.@@Madsen SM, Beck HC, Ravn P, Vrang A, Hansen AM, Israelsen H: Cloning and inactivation of a branched-chain-amino-acid aminotransferase gene from Staphylococcus carnosus and characterization of the enzyme. Appl Environ Microbiol. 2002 Aug;68(8):4007-14. |
| Groups | Investigational; Nutraceutical |
| Direct Classification | Isoleucine and derivatives |
| SMILES | CC[C@H](C)[C@H](N)C(O)=O |
| Pathways | 3-Methylglutaconic Aciduria Type III; 3-Methylglutaconic Aciduria Type I; beta-Ketothiolase Deficiency; Demeclocycline Action Pathway; Josamycin Action Pathway; Gentamicin Action Pathway; Lincomycin Action Pathway; Isobutyryl-CoA Dehydrogenase Deficiency; Methacycline Action Pathway; Clarithromycin Action Pathway; Minocycline Action Pathway; Paromomycin Action Pathway; Lymecycline Action Pathway; 2-Methyl-3-hydroxybutryl-CoA Dehydrogenase Deficiency; 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency; Troleandomycin Action Pathway; Amikacin Action Pathway; Methylmalonic Aciduria; Oxytetracycline Action Pathway; Tetracycline Action Pathway; Spectinomycin Action Pathway; Doxycycline Action Pathway; 3-Methylglutaconic Aciduria Type IV; Telithromycin Action Pathway; Roxithromycin Action Pathway; Tigecycline Action Pathway; Valine, Leucine, and Isoleucine Degradation; Arbekacin Action Pathway; Isovaleric Acidemia; Chloramphenicol Action Pathway |
| PharmGKB | PA164750430 |
| ChEMBL | CHEMBL1233584 |
