| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30004613 | HIV | ENSG00000178999.13 | protein_coding | AURKB | Yes | No | 9212 | Q96GD4 |
| TVIS30004614 | HIV | ENSG00000178999.13 | protein_coding | AURKB | Yes | No | 9212 | Q96GD4 |
| TVIS30042949 | HIV | ENSG00000178999.13 | protein_coding | AURKB | Yes | No | 9212 | Q96GD4 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | AURKB |
|---|---|
| DrugBank ID | DB12756 |
| Drug Name | TAK-901 |
| Target ID | BE0003404 |
| UniProt ID | Q96GD4 |
| Regulation Type | inhibitor |
| PubMed IDs | 28179288; 24332383 |
| Citations | Murai S, Matuszkiewicz J, Okuzono Y, Miya H, DE Jong R: Aurora B Inhibitor TAK-901 Synergizes with BCL-xL Inhibition by Inducing Active BAX in Cancer Cells. Anticancer Res. 2017 Feb;37(2):437-444. doi: 10.21873/anticanres.11335.@@Cullinane C, Waldeck KL, Binns D, Bogatyreva E, Bradley DP, de Jong R, McArthur GA, Hicks RJ: Preclinical FLT-PET and FDG-PET imaging of tumor response to the multi-targeted Aurora B kinase inhibitor, TAK-901. Nucl Med Biol. 2014 Feb;41(2):148-54. doi: 10.1016/j.nucmedbio.2013.11.001. Epub 2013 Nov 15. |
| Groups | Investigational |
| Direct Classification | Alpha carbolines |
| SMILES | CCS(=O)(=O)C1=CC=CC(=C1)C1=CC(C(=O)NC2CCN(C)CC2)=C(C)C2=C1C1=C(N2)N=CC(C)=C1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL3544932 |
