| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44016831 | HTLV-1 | ENSG00000153956.17 | protein_coding | CACNA2D1 | No | No | 781 | E7ERK3 P54289 Q9UIU0 |
| TVIS44045569 | HTLV-1 | ENSG00000153956.17 | protein_coding | CACNA2D1 | No | No | 781 | E7ERK3 P54289 Q9UIU0 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CACNA2D1 |
|---|---|
| DrugBank ID | DB00996 |
| Drug Name | Gabapentin |
| Target ID | BE0000691 |
| UniProt ID | P54289 |
| Regulation Type | inhibitor |
| PubMed IDs | 17067834; 18299583; 23435945 |
| Citations | Maneuf YP, Luo ZD, Lee K: alpha2delta and the mechanism of action of gabapentin in the treatment of pain. Semin Cell Dev Biol. 2006 Oct;17(5):565-70. Epub 2006 Sep 24.@@Hendrich J, Van Minh AT, Heblich F, Nieto-Rostro M, Watschinger K, Striessnig J, Wratten J, Davies A, Dolphin AC: Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin. Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3628-33. doi: 10.1073/pnas.0708930105. Epub 2008 Feb 25.@@Kukkar A, Bali A, Singh N, Jaggi AS: Implications and mechanism of action of gabapentin in neuropathic pain. Arch Pharm Res. 2013 Mar;36(3):237-51. doi: 10.1007/s12272-013-0057-y. Epub 2013 Feb 24. |
| Groups | Approved; Investigational |
| Direct Classification | Gamma amino acids and derivatives |
| SMILES | NCC1(CC(O)=O)CCCCC1 |
| Pathways | |
| PharmGKB | PA449720 |
| ChEMBL | CHEMBL940 |
