Target Gene Table ▼
VIS IDVirusEnsembl IDGene TypeTarget GeneOncogeneTumor Suppressor GeneNCBI IDUniprot ID
TVIS42001004EBVENSG00000140009.19protein_codingESR2NoNo2100Q92731
TVIS10045761HBVENSG00000140009.19protein_codingESR2NoNo2100Q92731
TVIS10045762HBVENSG00000140009.19protein_codingESR2NoNo2100Q92731
TVIS30036598HIVENSG00000140009.19protein_codingESR2NoNo2100Q92731
TVIS30036599HIVENSG00000140009.19protein_codingESR2NoNo2100Q92731
TVIS30036600HIVENSG00000140009.19protein_codingESR2NoNo2100Q92731
TVIS30036601HIVENSG00000140009.19protein_codingESR2NoNo2100Q92731
TVIS20017167HPVENSG00000140009.19protein_codingESR2NoNo2100Q92731
TVIS20051518HPVENSG00000140009.19protein_codingESR2NoNo2100Q92731
TVIS20034451HPVENSG00000140009.19protein_codingESR2NoNo2100Q92731
TCGA Plot Options ▼
Drug Information ▼
GeneESR2
DrugBank IDDB00675
Drug NameTamoxifen
Target IDBE0000792
UniProt IDQ92731
Regulation Typeantagonist
PubMed IDs11752352; 16010412; 16326830; 16822624; 17158759; 17404078; 2011412; 20827267
CitationsChen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Chen B, Gajdos C, Dardes R, Kidwai N, Johnston SR, Dowsett M, Jordan VC: Potential of endogenous estrogen receptor beta to influence the selective ER modulator ERbeta complex. Int J Oncol. 2005 Aug;27(2):327-35.@@Horner-Glister E, Maleki-Dizaji M, Guerin CJ, Johnson SM, Styles J, White IN: Influence of oestradiol and tamoxifen on oestrogen receptors-alpha and -beta protein degradation and non-genomic signalling pathways in uterine and breast carcinoma cells. J Mol Endocrinol. 2005 Dec;35(3):421-32.@@Girault I, Bieche I, Lidereau R: Role of estrogen receptor alpha transcriptional coregulators in tamoxifen resistance in breast cancer. Maturitas. 2006 Jul 20;54(4):342-51. Epub 2006 Jul 5.@@Mc Ilroy M, Fleming FJ, Buggy Y, Hill AD, Young LS: Tamoxifen-induced ER-alpha-SRC-3 interaction in HER2 positive human breast cancer; a possible mechanism for ER isoform specific recurrence. Endocr Relat Cancer. 2006 Dec;13(4):1135-45.@@Gruvberger-Saal SK, Bendahl PO, Saal LH, Laakso M, Hegardt C, Eden P, Peterson C, Malmstrom P, Isola J, Borg A, Ferno M: Estrogen receptor beta expression is associated with tamoxifen response in ERalpha-negative breast carcinoma. Clin Cancer Res. 2007 Apr 1;13(7):1987-94.@@Sasson S: Equilibrium binding analysis of estrogen agonists and antagonists: relation to the activation of the estrogen receptor. Pathol Biol (Paris). 1991 Jan;39(1):59-69.@@Hayes DF, Skaar TC, Rae JM, Henry NL, Nguyen AT, Stearns V, Li L, Philips S, Desta Z, Flockhart DA: Estrogen receptor genotypes, menopausal status, and the effects of tamoxifen on lipid levels: revised and updated results. Clin Pharmacol Ther. 2010 Nov;88(5):626-9. doi: 10.1038/clpt.2010.143. Epub 2010 Sep 8.
GroupsApproved
Direct ClassificationStilbenes
SMILESCCC(=C(/C1=CC=CC=C1)C1=CC=C(OCCN(C)C)C=C1)C1=CC=CC=C1
PathwaysTamoxifen Metabolism Pathway; Tamoxifen Action Pathway
PharmGKBPA451581
ChEMBLCHEMBL83