| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44013062 | HTLV-1 | ENSG00000101180.17 | protein_coding | HRH3 | No | No | 11255 | Q9Y5N1 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | HRH3 |
|---|---|
| DrugBank ID | DB11642 |
| Drug Name | Pitolisant |
| Target ID | BE0000968 |
| UniProt ID | Q9Y5N1 |
| Regulation Type | antagonist |
| PubMed IDs | 21615387; 27303254; 22356925 |
| Citations | Schwartz JC: The histamine H3 receptor: from discovery to clinical trials with pitolisant. Br J Pharmacol. 2011 Jun;163(4):713-21. doi: 10.1111/j.1476-5381.2011.01286.x.@@Khanfar MA, Affini A, Lutsenko K, Nikolic K, Butini S, Stark H: Multiple Targeting Approaches on Histamine H3 Receptor Antagonists. Front Neurosci. 2016 May 30;10:201. doi: 10.3389/fnins.2016.00201. eCollection 2016.@@Inocente C, Arnulf I, Bastuji H, Thibault-Stoll A, Raoux A, Reimao R, Lin JS, Franco P: Pitolisant, an inverse agonist of the histamine H3 receptor: an alternative stimulant for narcolepsy-cataplexy in teenagers with refractory sleepiness. Clin Neuropharmacol. 2012 Mar-Apr;35(2):55-60. doi: 10.1097/WNF.0b013e318246879d. |
| Groups | Approved; Investigational |
| Direct Classification | Chlorobenzenes |
| SMILES | ClC1=CC=C(CCCOCCCN2CCCCC2)C=C1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL462605 |
