| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10011228 | HBV | ENSG00000171608.18 | protein_coding | PIK3CD | Yes | No | 5293 | O00329 |
| TVIS30005072 | HIV | ENSG00000171608.18 | protein_coding | PIK3CD | Yes | No | 5293 | O00329 |
| TVIS30005073 | HIV | ENSG00000171608.18 | protein_coding | PIK3CD | Yes | No | 5293 | O00329 |
| TVIS30001457 | HIV | ENSG00000171608.18 | protein_coding | PIK3CD | Yes | No | 5293 | O00329 |
| TVIS30011160 | HIV | ENSG00000171608.18 | protein_coding | PIK3CD | Yes | No | 5293 | O00329 |
| TVIS30014456 | HIV | ENSG00000171608.18 | protein_coding | PIK3CD | Yes | No | 5293 | O00329 |
| TVIS30011161 | HIV | ENSG00000171608.18 | protein_coding | PIK3CD | Yes | No | 5293 | O00329 |
| TVIS30005074 | HIV | ENSG00000171608.18 | protein_coding | PIK3CD | Yes | No | 5293 | O00329 |
| TVIS30001458 | HIV | ENSG00000171608.18 | protein_coding | PIK3CD | Yes | No | 5293 | O00329 |
| TVIS30011162 | HIV | ENSG00000171608.18 | protein_coding | PIK3CD | Yes | No | 5293 | O00329 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PIK3CD |
|---|---|
| DrugBank ID | DB11952 |
| Drug Name | Duvelisib |
| Target ID | BE0002406 |
| UniProt ID | O00329 |
| Regulation Type | inhibitor |
| PubMed IDs | 24244039; 28945111; 28388280 |
| Citations | Boyle DL, Kim HR, Topolewski K, Bartok B, Firestein GS: Novel phosphoinositide 3-kinase delta,gamma inhibitor: potent anti-inflammatory effects and joint protection in models of rheumatoid arthritis. J Pharmacol Exp Ther. 2014 Feb;348(2):271-80. doi: 10.1124/jpet.113.205955. Epub 2013 Nov 15.@@Lampson BL, Brown JR: PI3Kdelta-selective and PI3Kalpha/delta-combinatorial inhibitors in clinical development for B-cell non-Hodgkin lymphoma. Expert Opin Investig Drugs. 2017 Nov;26(11):1267-1279. doi: 10.1080/13543784.2017.1384815. Epub 2017 Oct 6.@@Vangapandu HV, Jain N, Gandhi V: Duvelisib: a phosphoinositide-3 kinase delta/gamma inhibitor for chronic lymphocytic leukemia. Expert Opin Investig Drugs. 2017 May;26(5):625-632. doi: 10.1080/13543784.2017.1312338. Epub 2017 Apr 13. |
| Groups | Approved; Investigational |
| Direct Classification | Isoquinolones and derivatives |
| SMILES | C[C@H](NC1=C2N=CNC2=NC=N1)C1=CC2=CC=CC(Cl)=C2C(=O)N1C1=CC=CC=C1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL3039502 |
