| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30010644 | HIV | ENSG00000134318.16 | protein_coding | ROCK2 | No | No | 9475 | O75116 Q14DU5 |
| TVIS30074199 | HIV | ENSG00000134318.16 | protein_coding | ROCK2 | No | No | 9475 | O75116 Q14DU5 |
| TVIS30077253 | HIV | ENSG00000134318.16 | protein_coding | ROCK2 | No | No | 9475 | O75116 Q14DU5 |
| TVIS30087682 | HIV | ENSG00000134318.16 | protein_coding | ROCK2 | No | No | 9475 | O75116 Q14DU5 |
| TVIS30076943 | HIV | ENSG00000134318.16 | protein_coding | ROCK2 | No | No | 9475 | O75116 Q14DU5 |
| TVIS30049581 | HIV | ENSG00000134318.16 | protein_coding | ROCK2 | No | No | 9475 | O75116 Q14DU5 |
| TVIS30049582 | HIV | ENSG00000134318.16 | protein_coding | ROCK2 | No | No | 9475 | O75116 Q14DU5 |
| TVIS30049583 | HIV | ENSG00000134318.16 | protein_coding | ROCK2 | No | No | 9475 | O75116 Q14DU5 |
| TVIS30049584 | HIV | ENSG00000134318.16 | protein_coding | ROCK2 | No | No | 9475 | O75116 Q14DU5 |
| TVIS30049585 | HIV | ENSG00000134318.16 | protein_coding | ROCK2 | No | No | 9475 | O75116 Q14DU5 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ROCK2 |
|---|---|
| DrugBank ID | DB16703 |
| Drug Name | Belumosudil |
| Target ID | BE0004191 |
| UniProt ID | O75116 |
| Regulation Type | inhibitor |
| PubMed IDs | 34265047 |
| Citations | Cutler CS, Lee SJ, Arai S, Rotta M, Zoghi B, Lazaryan A, Ramakrishnan A, DeFilipp Z, Salhotra A, Chai-Ho W, Mehta RS, Wang T, Arora M, Pusic I, Saad A, Shah NN, Abhyankar S, Bachier C, Galvin JP, Im A, Langston A, Liesveld JL, Juckett M, Logan A, Schachter L, Alavi A, Howard DS, Waksal H, Ryan J, Eiznhamer D, Aggarwal SK, Ieyoub J, Schueller O, Green LS, Yang Z, Krenz H, Jagasia M, Blazar BR, Pavletic SZ: Belumosudil for Chronic Graft-versus-Host Disease (cGVHD) After 2 or More Prior Lines of Therapy: The ROCKstar Study. Blood. 2021 Jul 15. pii: 476399. doi: 10.1182/blood.2021012021. |
| Groups | Approved; Investigational |
| Direct Classification | |
| SMILES | CC(C)NC(=O)COC1=CC=CC(=C1)C1=NC2=C(C=CC=C2)C(NC2=CC=C3NN=CC3=C2)=N1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL2005186 |
