| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS42000653 | EBV | ENSG00000186951.17 | protein_coding | PPARA | No | No | 5465 | Q07869 |
| TVIS30013028 | HIV | ENSG00000186951.17 | protein_coding | PPARA | No | No | 5465 | Q07869 |
| TVIS30078106 | HIV | ENSG00000186951.17 | protein_coding | PPARA | No | No | 5465 | Q07869 |
| TVIS30055932 | HIV | ENSG00000186951.17 | protein_coding | PPARA | No | No | 5465 | Q07869 |
| TVIS30055933 | HIV | ENSG00000186951.17 | protein_coding | PPARA | No | No | 5465 | Q07869 |
| TVIS30055934 | HIV | ENSG00000186951.17 | protein_coding | PPARA | No | No | 5465 | Q07869 |
| TVIS30055935 | HIV | ENSG00000186951.17 | protein_coding | PPARA | No | No | 5465 | Q07869 |
| TVIS30055936 | HIV | ENSG00000186951.17 | protein_coding | PPARA | No | No | 5465 | Q07869 |
| TVIS30055937 | HIV | ENSG00000186951.17 | protein_coding | PPARA | No | No | 5465 | Q07869 |
| TVIS30055938 | HIV | ENSG00000186951.17 | protein_coding | PPARA | No | No | 5465 | Q07869 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PPARA |
|---|---|
| DrugBank ID | DB00636 |
| Drug Name | Clofibrate |
| Target ID | BE0000071 |
| UniProt ID | Q07869 |
| Regulation Type | agonist |
| PubMed IDs | 10454501; 10753628; 10787442; 10922459; 10951268; 20671072; 20637823 |
| Citations | Barclay TB, Peters JM, Sewer MB, Ferrari L, Gonzalez FJ, Morgan ET: Modulation of cytochrome P-450 gene expression in endotoxemic mice is tissue specific and peroxisome proliferator-activated receptor-alpha dependent. J Pharmacol Exp Ther. 1999 Sep;290(3):1250-7.@@Murata M, Kaji H, Takahashi Y, Iida K, Mizuno I, Okimura Y, Abe H, Chihara K: Stimulation by eicosapentaenoic acids of leptin mRNA expression and its secretion in mouse 3T3-L1 adipocytes in vitro. Biochem Biophys Res Commun. 2000 Apr 13;270(2):343-8.@@Hunt MC, Lindquist PJ, Peters JM, Gonzalez FJ, Diczfalusy U, Alexson SE: Involvement of the peroxisome proliferator-activated receptor alpha in regulating long-chain acyl-CoA thioesterases. J Lipid Res. 2000 May;41(5):814-23.@@Casas F, Domenjoud L, Rochard P, Hatier R, Rodier A, Daury L, Bianchi A, Kremarik-Bouillaud P, Becuwe P, Keller J, Schohn H, Wrutniak-Cabello C, Cabello G, Dauca M: A 45 kDa protein related to PPARgamma2, induced by peroxisome proliferators, is located in the mitochondrial matrix. FEBS Lett. 2000 Jul 28;478(1-2):4-8.@@Komuves LG, Hanley K, Lefebvre AM, Man MQ, Ng DC, Bikle DD, Williams ML, Elias PM, Auwerx J, Feingold KR: Stimulation of PPARalpha promotes epidermal keratinocyte differentiation in vivo. J Invest Dermatol. 2000 Sep;115(3):353-60.@@Gelosa P, Banfi C, Gianella A, Brioschi M, Pignieri A, Nobili E, Castiglioni L, Cimino M, Tremoli E, Sironi L: Peroxisome proliferator-activated receptor {alpha} agonism prevents renal damage and the oxidative stress and inflammatory processes affecting the brains of stroke-prone rats. J Pharmacol Exp Ther. 2010 Nov;335(2):324-31. doi: 10.1124/jpet.110.171090. Epub 2010 Jul 29.@@Palkar PS, Anderson CR, Ferry CH, Gonzalez FJ, Peters JM: Effect of prenatal peroxisome proliferator-activated receptor alpha (PPARalpha) agonism on postnatal development. Toxicology. 2010 Sep 30;276(1):79-84. doi: 10.1016/j.tox.2010.07.008. Epub 2010 Jul 15. |
| Groups | Approved; Investigational |
| Direct Classification | Phenoxyacetic acid derivatives |
| SMILES | CCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 |
| Pathways | |
| PharmGKB | PA449045 |
| ChEMBL | CHEMBL565 |
