| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20017201 | HPV | ENSG00000154229.12 | protein_coding | PRKCA | No | No | 5578 | P17252 Q7Z727 |
| TVIS20017202 | HPV | ENSG00000154229.12 | protein_coding | PRKCA | No | No | 5578 | P17252 Q7Z727 |
| TVIS20039910 | HPV | ENSG00000154229.12 | protein_coding | PRKCA | No | No | 5578 | P17252 Q7Z727 |
| TVIS20036459 | HPV | ENSG00000154229.12 | protein_coding | PRKCA | No | No | 5578 | P17252 Q7Z727 |
| TVIS44012280 | HTLV-1 | ENSG00000154229.12 | protein_coding | PRKCA | No | No | 5578 | P17252 Q7Z727 |
| TVIS44027485 | HTLV-1 | ENSG00000154229.12 | protein_coding | PRKCA | No | No | 5578 | P17252 Q7Z727 |
| TVIS44014592 | HTLV-1 | ENSG00000154229.12 | protein_coding | PRKCA | No | No | 5578 | P17252 Q7Z727 |
| TVIS44006953 | HTLV-1 | ENSG00000154229.12 | protein_coding | PRKCA | No | No | 5578 | P17252 Q7Z727 |
| TVIS44032797 | HTLV-1 | ENSG00000154229.12 | protein_coding | PRKCA | No | No | 5578 | P17252 Q7Z727 |
| TVIS44027486 | HTLV-1 | ENSG00000154229.12 | protein_coding | PRKCA | No | No | 5578 | P17252 Q7Z727 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PRKCA |
|---|---|
| DrugBank ID | DB06595 |
| Drug Name | Midostaurin |
| Target ID | BE0001132 |
| UniProt ID | P17252 |
| Regulation Type | antagonist |
| PubMed IDs | 16969355 |
| Citations | Millward MJ, House C, Bowtell D, Webster L, Olver IN, Gore M, Copeman M, Lynch K, Yap A, Wang Y, Cohen PS, Zalcberg J: The multikinase inhibitor midostaurin (PKC412A) lacks activity in metastatic melanoma: a phase IIA clinical and biologic study. Br J Cancer. 2006 Oct 9;95(7):829-34. Epub 2006 Sep 12. |
| Groups | Approved; Investigational |
| Direct Classification | Indolocarbazoles |
| SMILES | CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)N1C3=C(C=CC=C3)C3=C1C1=C(C4=C(C=CC=C4)N21)C1=C3CNC1=O)N(C)C(=O)C1=CC=CC=C1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL608533 |
