| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10039826 | HBV | ENSG00000164879.7 | protein_coding | CA3 | No | No | 761 | P07451 |
| TVIS30075681 | HIV | ENSG00000164879.7 | protein_coding | CA3 | No | No | 761 | P07451 |
| TVIS20005424 | HPV | ENSG00000164879.7 | protein_coding | CA3 | No | No | 761 | P07451 |
| TVIS20062836 | HPV | ENSG00000164879.7 | protein_coding | CA3 | No | No | 761 | P07451 |
| TVIS20031257 | HPV | ENSG00000164879.7 | protein_coding | CA3 | No | No | 761 | P07451 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CA3 |
|---|---|
| DrugBank ID | DB00909 |
| Drug Name | Zonisamide |
| Target ID | BE0003625 |
| UniProt ID | P07451 |
| Regulation Type | inhibitor |
| PubMed IDs | 19703035; 18537527; 18782051; 17762320; 17582922; 15837316; 18343915; 8494570 |
| Citations | De Simone G, Scozzafava A, Supuran CT: Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates? Chem Biol Drug Des. 2009 Sep;74(3):317-21. doi: 10.1111/j.1747-0285.2009.00857.x.@@Supuran CT, Di Fiore A, De Simone G: Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity. Expert Opin Emerg Drugs. 2008 Jun;13(2):383-92. doi: 10.1517/14728214.13.2.383 .@@Farooq MU, Moore PW, Bhatt A, Aburashed R, Kassab MY: Therapeutic role of zonisamide in neuropsychiatric disorders. Mini Rev Med Chem. 2008 Sep;8(10):968-75.@@Biton V: Clinical pharmacology and mechanism of action of zonisamide. Clin Neuropharmacol. 2007 Jul-Aug;30(4):230-40.@@Authors unspecified: Zonisamide: new drug. No advantage in refractory partial epilepsy. Prescrire Int. 2007 Jun;16(89):95-7.@@De Simone G, Di Fiore A, Menchise V, Pedone C, Antel J, Casini A, Scozzafava A, Wurl M, Supuran CT: Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies. Bioorg Med Chem Lett. 2005 May 2;15(9):2315-20.@@Shank RP, Smith-Swintosky VL, Maryanoff BE: Carbonic anhydrase inhibition. Insight into the characteristics of zonisamide, topiramate, and the sulfamide cognate of topiramate. J Enzyme Inhib Med Chem. 2008 Apr;23(2):271-6. doi: 10.1080/14756360701507001 .@@Masuda Y, Karasawa T: Inhibitory effect of zonisamide on human carbonic anhydrase in vitro. Arzneimittelforschung. 1993 Apr;43(4):416-8. |
| Groups | Approved; Investigational |
| Direct Classification | Benzisoxazoles |
| SMILES | NS(=O)(=O)CC1=NOC2=CC=CC=C12 |
| Pathways | |
| PharmGKB | PA451978 |
| ChEMBL | CHEMBL750 |
