| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30012271 | HIV | ENSG00000278540.5 | protein_coding | ACACA | No | No | 31 | B2ZZ90 Q13085 Q7Z5W8 |
| TVIS30001041 | HIV | ENSG00000278540.5 | protein_coding | ACACA | No | No | 31 | B2ZZ90 Q13085 Q7Z5W8 |
| TVIS30004631 | HIV | ENSG00000278540.5 | protein_coding | ACACA | No | No | 31 | B2ZZ90 Q13085 Q7Z5W8 |
| TVIS30074802 | HIV | ENSG00000278540.5 | protein_coding | ACACA | No | No | 31 | B2ZZ90 Q13085 Q7Z5W8 |
| TVIS30074803 | HIV | ENSG00000278540.5 | protein_coding | ACACA | No | No | 31 | B2ZZ90 Q13085 Q7Z5W8 |
| TVIS30043655 | HIV | ENSG00000278540.5 | protein_coding | ACACA | No | No | 31 | B2ZZ90 Q13085 Q7Z5W8 |
| TVIS30043656 | HIV | ENSG00000278540.5 | protein_coding | ACACA | No | No | 31 | B2ZZ90 Q13085 Q7Z5W8 |
| TVIS20038734 | HPV | ENSG00000278540.5 | protein_coding | ACACA | No | No | 31 | B2ZZ90 Q13085 Q7Z5W8 |
| TVIS20018748 | HPV | ENSG00000278540.5 | protein_coding | ACACA | No | No | 31 | B2ZZ90 Q13085 Q7Z5W8 |
| TVIS20018749 | HPV | ENSG00000278540.5 | protein_coding | ACACA | No | No | 31 | B2ZZ90 Q13085 Q7Z5W8 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ACACA |
|---|---|
| DrugBank ID | DB00121 |
| Drug Name | Biotin |
| Target ID | BE0000626 |
| UniProt ID | Q13085 |
| Regulation Type | cofactor |
| PubMed IDs | 16460018; 16545081; 16636450; 16707089; 17468269; 16772434 |
| Citations | Bilder P, Lightle S, Bainbridge G, Ohren J, Finzel B, Sun F, Holley S, Al-Kassim L, Spessard C, Melnick M, Newcomer M, Waldrop GL: The structure of the carboxyltransferase component of acetyl-coA carboxylase reveals a zinc-binding motif unique to the bacterial enzyme. Biochemistry. 2006 Feb 14;45(6):1712-22.@@Brownsey RW, Boone AN, Elliott JE, Kulpa JE, Lee WM: Regulation of acetyl-CoA carboxylase. Biochem Soc Trans. 2006 Apr;34(Pt 2):223-7.@@Aoki H, Kimura K, Igarashi K, Takenaka A: Soy protein suppresses gene expression of acetyl-coA carboxylase alpha from promoter PI in rat liver. Biosci Biotechnol Biochem. 2006 Apr;70(4):843-9.@@Santoro N, Brtva T, Roest SV, Siegel K, Waldrop GL: A high-throughput screening assay for the carboxyltransferase subunit of acetyl-CoA carboxylase. Anal Biochem. 2006 Jul 1;354(1):70-7. Epub 2006 May 3.@@Leonard E, Lim KH, Saw PN, Koffas MA: Engineering central metabolic pathways for high-level flavonoid production in Escherichia coli. Appl Environ Microbiol. 2007 Jun;73(12):3877-86. Epub 2007 Apr 27.@@Hassan YI, Zempleni J: Epigenetic regulation of chromatin structure and gene function by biotin. J Nutr. 2006 Jul;136(7):1763-5. |
| Groups | Approved; Investigational; Nutraceutical |
| Direct Classification | Biotin and derivatives |
| SMILES | [H][C@]12CS[C@@H](CCCCC(O)=O)[C@@]1([H])NC(=O)N2 |
| Pathways | Mitochondrial Complex II Deficiency; 3-Methylglutaconic Aciduria Type III; 2-Ketoglutarate Dehydrogenase Complex Deficiency; 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency; Isovaleric Aciduria; Pyruvate Carboxylase Deficiency; Warburg Effect; Isobutyryl-CoA Dehydrogenase Deficiency; Biotin Metabolism; Fructose-1,6-diphosphatase Deficiency; Methylmalonic Aciduria Due to Cobalamin-Related Disorders; Propionic Acidemia; Transfer of Acetyl Groups into Mitochondria; Malonic Aciduria; 2-Hydroxyglutric Aciduria (D and L Form); 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I; Congenital Lactic Acidosis; 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency; Fumarase Deficiency; Succinic Semialdehyde Dehydrogenase Deficiency; Alanine Metabolism; Methylmalonic Aciduria; 3-Methylglutaconic Aciduria Type IV; Lactic Acidemia; Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease; Primary Hyperoxaluria Type I; Triosephosphate Isomerase; The Oncogenic Action of 2-Hydroxyglutarate; Valine, Leucine, and Isoleucine Degradation; Maple Syrup Urine Disease |
| PharmGKB | PA448625 |
| ChEMBL | CHEMBL857 |
