| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44028618 | HTLV-1 | ENSG00000108684.15 | protein_coding | ASIC2 | No | No | 40 | Q16515 |
| TVIS44010450 | HTLV-1 | ENSG00000108684.15 | protein_coding | ASIC2 | No | No | 40 | Q16515 |
| TVIS44021129 | HTLV-1 | ENSG00000108684.15 | protein_coding | ASIC2 | No | No | 40 | Q16515 |
| TVIS44008322 | HTLV-1 | ENSG00000108684.15 | protein_coding | ASIC2 | No | No | 40 | Q16515 |
| TVIS44021130 | HTLV-1 | ENSG00000108684.15 | protein_coding | ASIC2 | No | No | 40 | Q16515 |
| TVIS44027435 | HTLV-1 | ENSG00000108684.15 | protein_coding | ASIC2 | No | No | 40 | Q16515 |
| TVIS44018000 | HTLV-1 | ENSG00000108684.15 | protein_coding | ASIC2 | No | No | 40 | Q16515 |
| TVIS44018001 | HTLV-1 | ENSG00000108684.15 | protein_coding | ASIC2 | No | No | 40 | Q16515 |
| TVIS44027436 | HTLV-1 | ENSG00000108684.15 | protein_coding | ASIC2 | No | No | 40 | Q16515 |
| TVIS44011657 | HTLV-1 | ENSG00000108684.15 | protein_coding | ASIC2 | No | No | 40 | Q16515 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ASIC2 |
|---|---|
| DrugBank ID | DB00594 |
| Drug Name | Amiloride |
| Target ID | BE0000678 |
| UniProt ID | Q16515 |
| Regulation Type | inhibitor |
| PubMed IDs | 12584187; 12736332; 14686475; 15537887; 16704974 |
| Citations | Berdiev BK, Xia J, McLean LA, Markert JM, Gillespie GY, Mapstone TB, Naren AP, Jovov B, Bubien JK, Ji HL, Fuller CM, Kirk KL, Benos DJ: Acid-sensing ion channels in malignant gliomas. J Biol Chem. 2003 Apr 25;278(17):15023-34. Epub 2003 Feb 12.@@Ugawa S, Yamamoto T, Ueda T, Ishida Y, Inagaki A, Nishigaki M, Shimada S: Amiloride-insensitive currents of the acid-sensing ion channel-2a (ASIC2a)/ASIC2b heteromeric sour-taste receptor channel. J Neurosci. 2003 May 1;23(9):3616-22.@@Ugawa S: Identification of sour-taste receptor genes. Anat Sci Int. 2003 Dec;78(4):205-10.@@Peng BG, Ahmad S, Chen S, Chen P, Price MP, Lin X: Acid-sensing ion channel 2 contributes a major component to acid-evoked excitatory responses in spiral ganglion neurons and plays a role in noise susceptibility of mice. J Neurosci. 2004 Nov 10;24(45):10167-75.@@Vila-Carriles WH, Kovacs GG, Jovov B, Zhou ZH, Pahwa AK, Colby G, Esimai O, Gillespie GY, Mapstone TB, Markert JM, Fuller CM, Bubien JK, Benos DJ: Surface expression of ASIC2 inhibits the amiloride-sensitive current and migration of glioma cells. J Biol Chem. 2006 Jul 14;281(28):19220-32. Epub 2006 May 16. |
| Groups | Approved |
| Direct Classification | Aminopyrazines |
| SMILES | NC(=N)NC(=O)C1=NC(Cl)=C(N)N=C1N |
| Pathways | Amiloride Action Pathway |
| PharmGKB | PA448368 |
| ChEMBL | CHEMBL945 |
