Target Gene Table
VIS IDVirusEnsembl IDGene TypeTarget GeneOncogeneTumor Suppressor GeneNCBI IDUniprot ID
TVIS30077228HIVENSG00000107779.16protein_codingBMPR1ANoYes657P36894
TVIS30028074HIVENSG00000107779.16protein_codingBMPR1ANoYes657P36894
TVIS30019944HIVENSG00000107779.16protein_codingBMPR1ANoYes657P36894
TVIS30028075HIVENSG00000107779.16protein_codingBMPR1ANoYes657P36894
TVIS30028076HIVENSG00000107779.16protein_codingBMPR1ANoYes657P36894
TVIS20043630HPVENSG00000107779.16protein_codingBMPR1ANoYes657P36894
TVIS20038084HPVENSG00000107779.16protein_codingBMPR1ANoYes657P36894
TVIS20036682HPVENSG00000107779.16protein_codingBMPR1ANoYes657P36894
TVIS20049104HPVENSG00000107779.16protein_codingBMPR1ANoYes657P36894
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Drug Information
GeneBMPR1A
DrugBank IDDB11639
Drug NameDibotermin alfa
Target IDBE0009272
UniProt IDP36894
Regulation Typeligand
PubMed IDs11263668; 10692589; 10880444; 10712517
CitationsNickel J, Dreyer MK, Kirsch T, Sebald W: The crystal structure of the BMP-2:BMPR-IA complex and the generation of BMP-2 antagonists. J Bone Joint Surg Am. 2001;83-A Suppl 1(Pt 1):S7-14.@@Kirsch T, Nickel J, Sebald W: Isolation of recombinant BMP receptor IA ectodomain and its 2:1 complex with BMP-2. FEBS Lett. 2000 Feb 25;468(2-3):215-9.@@Kirsch T, Nickel J, Sebald W: BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II. EMBO J. 2000 Jul 3;19(13):3314-24. doi: 10.1093/emboj/19.13.3314.@@Gilboa L, Nohe A, Geissendorfer T, Sebald W, Henis YI, Knaus P: Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors. Mol Biol Cell. 2000 Mar;11(3):1023-35.
GroupsApproved; Investigational
Direct ClassificationPeptides
SMILES
Pathways
PharmGKB
ChEMBL