| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44010477 | HTLV-1 | ENSG00000157445.16 | protein_coding | CACNA2D3 | No | No | 55799 | Q8IZS8 |
| TVIS44014357 | HTLV-1 | ENSG00000157445.16 | protein_coding | CACNA2D3 | No | No | 55799 | Q8IZS8 |
| TVIS44001152 | HTLV-1 | ENSG00000157445.16 | protein_coding | CACNA2D3 | No | No | 55799 | Q8IZS8 |
| TVIS44011994 | HTLV-1 | ENSG00000157445.16 | protein_coding | CACNA2D3 | No | No | 55799 | Q8IZS8 |
| TVIS44019117 | HTLV-1 | ENSG00000157445.16 | protein_coding | CACNA2D3 | No | No | 55799 | Q8IZS8 |
| TVIS44029797 | HTLV-1 | ENSG00000157445.16 | protein_coding | CACNA2D3 | No | No | 55799 | Q8IZS8 |
| TVIS44019118 | HTLV-1 | ENSG00000157445.16 | protein_coding | CACNA2D3 | No | No | 55799 | Q8IZS8 |
| TVIS44019119 | HTLV-1 | ENSG00000157445.16 | protein_coding | CACNA2D3 | No | No | 55799 | Q8IZS8 |
| TVIS44025096 | HTLV-1 | ENSG00000157445.16 | protein_coding | CACNA2D3 | No | No | 55799 | Q8IZS8 |
| TVIS44019120 | HTLV-1 | ENSG00000157445.16 | protein_coding | CACNA2D3 | No | No | 55799 | Q8IZS8 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CACNA2D3 |
|---|---|
| DrugBank ID | DB00381 |
| Drug Name | Amlodipine |
| Target ID | BE0003563 |
| UniProt ID | Q8IZS8 |
| Regulation Type | inhibitor |
| PubMed IDs | 9249249; 10525060; 20097194; 11426839; 19634509; 10374627 |
| Citations | Furukawa T, Nukada T, Suzuki K, Fujita Y, Mori Y, Nishimura M, Yamanaka M: Voltage and pH dependent block of cloned N-type Ca2+ channels by amlodipine. Br J Pharmacol. 1997 Jul;121(6):1136-40.@@Furukawa T, Yamakawa T, Midera T, Sagawa T, Mori Y, Nukada T: Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes expressed in Xenopus oocytes. J Pharmacol Exp Ther. 1999 Nov;291(2):464-73.@@Miyashita Y, Furukawa T, Kamegaya E, Yoshii M, Nukada T: A region of N-type Ca(2+) channel critical for blockade by the dihydropyridine amlodipine. Eur J Pharmacol. 2010 Apr 25;632(1-3):14-22. doi: 10.1016/j.ejphar.2010.01.006. Epub 2010 Jan 22.@@Murakami M, Nakagawasai O, Fujii S, Kameyama K, Murakami S, Hozumi S, Esashi A, Taniguchi R, Yanagisawa T, Tan-no K, Tadano T, Kitamura K, Kisara K: Antinociceptive action of amlodipine blocking N-type Ca2+ channels at the primary afferent neurons in mice. Eur J Pharmacol. 2001 May 11;419(2-3):175-81.@@Ogihara T, Kano T, Kakinuma C: Evaluation of the inhibitory effect of dihydropyridines on N-type calcium channel by virtual three-dimensional pharmacophore modeling. Arzneimittelforschung. 2009;59(6):283-8. doi: 10.1055/s-0031-1296398.@@Qu YL, Sugiyama K, Ohnuki T, Hattori K, Watanabe K, Nagatomo T: Comparison of binding affinities of omega-conotoxin and amlodipine to N-type Ca2+ channels in rat brain. Zhongguo Yao Li Xue Bao. 1998 Mar;19(2):97-100. |
| Groups | Approved |
| Direct Classification | Dihydropyridinecarboxylic acids and derivatives |
| SMILES | CCOC(=O)C1=C(COCCN)NC(C)=C(C1C1=CC=CC=C1Cl)C(=O)OC |
| Pathways | Amlodipine Action Pathway |
| PharmGKB | PA448388 |
| ChEMBL | CHEMBL1491 |
