| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20053275 | HPV | ENSG00000169710.9 | protein_coding | FASN | No | No | 2194 | P49327 |
| TVIS44018068 | HTLV-1 | ENSG00000169710.9 | protein_coding | FASN | No | No | 2194 | P49327 |
| TVIS44051455 | HTLV-1 | ENSG00000169710.9 | protein_coding | FASN | No | No | 2194 | P49327 |
| TVIS44051456 | HTLV-1 | ENSG00000169710.9 | protein_coding | FASN | No | No | 2194 | P49327 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | FASN |
|---|---|
| DrugBank ID | DB01034 |
| Drug Name | Cerulenin |
| Target ID | BE0000959 |
| UniProt ID | P49327 |
| Regulation Type | inhibitor |
| PubMed IDs | 10102370; 11245456; 12181752; 11752352; 20373869; 17168665; 15878185 |
| Citations | Oskouian B, Saba JD: YAP1 confers resistance to the fatty acid synthase inhibitor cerulenin through the transporter Flr1p in Saccharomyces cerevisiae. Mol Gen Genet. 1999 Mar;261(2):346-53.@@Li JN, Gorospe M, Chrest FJ, Kumaravel TS, Evans MK, Han WF, Pizer ES: Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53. Cancer Res. 2001 Feb 15;61(4):1493-9.@@Heiligtag SJ, Bredehorst R, David KA: Key role of mitochondria in cerulenin-mediated apoptosis. Cell Death Differ. 2002 Sep;9(9):1017-25.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Flavin R, Peluso S, Nguyen PL, Loda M: Fatty acid synthase as a potential therapeutic target in cancer. Future Oncol. 2010 Apr;6(4):551-62. doi: 10.2217/fon.10.11.@@Lupu R, Menendez JA: Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents? Curr Pharm Biotechnol. 2006 Dec;7(6):483-93.@@Ronnett GV, Kim EK, Landree LE, Tu Y: Fatty acid metabolism as a target for obesity treatment. Physiol Behav. 2005 May 19;85(1):25-35. |
| Groups | Experimental |
| Direct Classification | |
| SMILES | [H][C@]1(O[C@]1([H])C(=O)CCC=CCC=CC)C(N)=O |
| Pathways | |
| PharmGKB | PA164764551 |
| ChEMBL | CHEMBL45627 |
