| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20009341 | HPV | ENSG00000116478.13 | protein_coding | HDAC1 | Yes | No | 3065 | Q13547 Q6IT96 |
| TVIS20068329 | HPV | ENSG00000116478.13 | protein_coding | HDAC1 | Yes | No | 3065 | Q13547 Q6IT96 |
| TVIS44006869 | HTLV-1 | ENSG00000116478.13 | protein_coding | HDAC1 | Yes | No | 3065 | Q13547 Q6IT96 |
| TVIS44004202 | HTLV-1 | ENSG00000116478.13 | protein_coding | HDAC1 | Yes | No | 3065 | Q13547 Q6IT96 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | HDAC1 |
|---|---|
| DrugBank ID | DB00313 |
| Drug Name | Valproic acid |
| Target ID | BE0008667 |
| UniProt ID | Q9UKV0 |
| Regulation Type | inhibitor |
| PubMed IDs | 28812434; 14576182; 19115247; 15870934; 12678732; 30562925; 18053801 |
| Citations | Booth L, Roberts JL, Poklepovic A, Dent P: [pemetrexed + sildenafil], via autophagy-dependent HDAC downregulation, enhances the immunotherapy response of NSCLC cells. Cancer Biol Ther. 2017 Sep 2;18(9):705-714. doi: 10.1080/15384047.2017.1362511.@@Nelson-DeGrave VL, Wickenheisser JK, Cockrell JE, Wood JR, Legro RS, Strauss JF 3rd, McAllister JM: Valproate potentiates androgen biosynthesis in human ovarian theca cells. Endocrinology. 2004 Feb;145(2):799-808. Epub 2003 Oct 23.@@Chabane N, Li X, Fahmi H: HDAC4 contributes to IL-1-induced mPGES-1 expression in human synovial fibroblasts through up-regulation of Egr-1 transcriptional activity. J Cell Biochem. 2009 Feb 15;106(3):453-63. doi: 10.1002/jcb.22027.@@Rocchi P, Tonelli R, Camerin C, Purgato S, Fronza R, Bianucci F, Guerra F, Pession A, Ferreri AM: p21Waf1/Cip1 is a common target induced by short-chain fatty acid HDAC inhibitors (valproic acid, tributyrin and sodium butyrate) in neuroblastoma cells. Oncol Rep. 2005 Jun;13(6):1139-44.@@Kouraklis G, Theocharis S: Histone deacetylase inhibitors and anticancer therapy. Curr Med Chem Anticancer Agents. 2002 Jul;2(4):477-84. doi: 10.2174/1568011023353921.@@Chang MC, Chen YJ, Lian YC, Chang BE, Huang CC, Huang WL, Pan YH, Jeng JH: Butyrate Stimulates Histone H3 Acetylation, 8-Isoprostane Production, RANKL Expression, and Regulated Osteoprotegerin Expression/Secretion in MG-63 Osteoblastic Cells. Int J Mol Sci. 2018 Dec 17;19(12). pii: ijms19124071. doi: 10.3390/ijms19124071.@@Matsumoto Y, Motoki T, Kubota S, Takigawa M, Tsubouchi H, Gohda E: Inhibition of tumor-stromal interaction through HGF/Met signaling by valproic acid. Biochem Biophys Res Commun. 2008 Feb 1;366(1):110-6. doi: 10.1016/j.bbrc.2007.11.089. Epub 2007 Nov 29. |
| Groups | Approved; Investigational |
| Direct Classification | Methyl-branched fatty acids |
| SMILES | CCCC(CCC)C(O)=O |
| Pathways | Valproic Acid Metabolism Pathway |
| PharmGKB | PA451846 |
| ChEMBL | CHEMBL109 |
