| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30005115 | HIV | ENSG00000004487.18 | protein_coding | KDM1A | No | No | 23028 | O60341 |
| TVIS30010056 | HIV | ENSG00000004487.18 | protein_coding | KDM1A | No | No | 23028 | O60341 |
| TVIS30011184 | HIV | ENSG00000004487.18 | protein_coding | KDM1A | No | No | 23028 | O60341 |
| TVIS30010057 | HIV | ENSG00000004487.18 | protein_coding | KDM1A | No | No | 23028 | O60341 |
| TVIS30018070 | HIV | ENSG00000004487.18 | protein_coding | KDM1A | No | No | 23028 | O60341 |
| TVIS30022586 | HIV | ENSG00000004487.18 | protein_coding | KDM1A | No | No | 23028 | O60341 |
| TVIS30022587 | HIV | ENSG00000004487.18 | protein_coding | KDM1A | No | No | 23028 | O60341 |
| TVIS30022588 | HIV | ENSG00000004487.18 | protein_coding | KDM1A | No | No | 23028 | O60341 |
| TVIS30022589 | HIV | ENSG00000004487.18 | protein_coding | KDM1A | No | No | 23028 | O60341 |
| TVIS30022590 | HIV | ENSG00000004487.18 | protein_coding | KDM1A | No | No | 23028 | O60341 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | KDM1A |
|---|---|
| DrugBank ID | DB16446 |
| Drug Name | Vafidemstat |
| Target ID | BE0010091 |
| UniProt ID | O60341 |
| Regulation Type | inhibitor |
| PubMed IDs | 33755924; 32469975 |
| Citations | Antonijoan RM, Ferrero-Cafiero JM, Coimbra J, Puntes M, Martinez-Colomer J, Arevalo MI, Mascaro C, Molinero C, Buesa C, Maes T: First-in-Human Randomized Trial to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of the KDM1A Inhibitor Vafidemstat. CNS Drugs. 2021 Mar;35(3):331-344. doi: 10.1007/s40263-021-00797-x. Epub 2021 Mar 23.@@Maes T, Mascaro C, Rotllant D, Lufino MMP, Estiarte A, Guibourt N, Cavalcanti F, Grinan-Ferre C, Pallas M, Nadal R, Armario A, Ferrer I, Ortega A, Valls N, Fyfe M, Martinell M, Castro Palomino JC, Buesa Arjol C: Modulation of KDM1A with vafidemstat rescues memory deficit and behavioral alterations. PLoS One. 2020 May 29;15(5):e0233468. doi: 10.1371/journal.pone.0233468. eCollection 2020. |
| Groups | Investigational |
| Direct Classification | |
| SMILES | NC1=NN=C(CN[C@@H]2C[C@H]2C2=CC=C(OCC3=CC=CC=C3)C=C2)O1 |
| Pathways | |
| PharmGKB | |
| ChEMBL |
