| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30023045 | HIV | ENSG00000182866.18 | protein_coding | LCK | Yes | No | 3932 | A0A0S2Z3Y4 A0A0S2Z3Y8 P06239 Q573B4 |
| TVIS30023046 | HIV | ENSG00000182866.18 | protein_coding | LCK | Yes | No | 3932 | A0A0S2Z3Y4 A0A0S2Z3Y8 P06239 Q573B4 |
| TVIS30023047 | HIV | ENSG00000182866.18 | protein_coding | LCK | Yes | No | 3932 | A0A0S2Z3Y4 A0A0S2Z3Y8 P06239 Q573B4 |
| TVIS30023048 | HIV | ENSG00000182866.18 | protein_coding | LCK | Yes | No | 3932 | A0A0S2Z3Y4 A0A0S2Z3Y8 P06239 Q573B4 |
| TVIS30023049 | HIV | ENSG00000182866.18 | protein_coding | LCK | Yes | No | 3932 | A0A0S2Z3Y4 A0A0S2Z3Y8 P06239 Q573B4 |
| TVIS44018658 | HTLV-1 | ENSG00000182866.18 | protein_coding | LCK | Yes | No | 3932 | A0A0S2Z3Y4 A0A0S2Z3Y8 P06239 Q573B4 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | LCK |
|---|---|
| DrugBank ID | DB01254 |
| Drug Name | Dasatinib |
| Target ID | BE0000842 |
| UniProt ID | P06239 |
| Regulation Type | inhibitor |
| PubMed IDs | 17154512; 20072833 |
| Citations | Das J, Chen P, Norris D, Padmanabha R, Lin J, Moquin RV, Shen Z, Cook LS, Doweyko AM, Pitt S, Pang S, Shen DR, Fang Q, de Fex HF, McIntyre KW, Shuster DJ, Gillooly KM, Behnia K, Schieven GL, Wityak J, Barrish JC: 2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase inhibitor. J Med Chem. 2006 Nov 16;49(23):6819-32.@@Lindauer M, Hochhaus A: Dasatinib. Recent Results Cancer Res. 2010;184:83-102. doi: 10.1007/978-3-642-01222-8_7. |
| Groups | Approved; Investigational |
| Direct Classification | Aromatic anilides |
| SMILES | CC1=NC(NC2=NC=C(S2)C(=O)NC2=C(C)C=CC=C2Cl)=CC(=N1)N1CCN(CCO)CC1 |
| Pathways | Dasatinib Inhibition of BCR-ABL |
| PharmGKB | PA162372878 |
| ChEMBL | CHEMBL1421 |
