| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30060816 | HIV | ENSG00000138795.10 | protein_coding | LEF1 | Yes | No | 51176 | Q9UJU2 |
| TVIS20045178 | HPV | ENSG00000138795.10 | protein_coding | LEF1 | Yes | No | 51176 | Q9UJU2 |
| TVIS20019085 | HPV | ENSG00000138795.10 | protein_coding | LEF1 | Yes | No | 51176 | Q9UJU2 |
| TVIS44025165 | HTLV-1 | ENSG00000138795.10 | protein_coding | LEF1 | Yes | No | 51176 | Q9UJU2 |
| TVIS44025166 | HTLV-1 | ENSG00000138795.10 | protein_coding | LEF1 | Yes | No | 51176 | Q9UJU2 |
| TVIS44034557 | HTLV-1 | ENSG00000138795.10 | protein_coding | LEF1 | Yes | No | 51176 | Q9UJU2 |
| TVIS44038745 | HTLV-1 | ENSG00000138795.10 | protein_coding | LEF1 | Yes | No | 51176 | Q9UJU2 |
| TVIS44050373 | HTLV-1 | ENSG00000138795.10 | protein_coding | LEF1 | Yes | No | 51176 | Q9UJU2 |
| TVIS44035230 | HTLV-1 | ENSG00000138795.10 | protein_coding | LEF1 | Yes | No | 51176 | Q9UJU2 |
| TVIS44048827 | HTLV-1 | ENSG00000138795.10 | protein_coding | LEF1 | Yes | No | 51176 | Q9UJU2 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | LEF1 |
|---|---|
| DrugBank ID | DB00903 |
| Drug Name | Etacrynic acid |
| Target ID | BE0009011 |
| UniProt ID | Q9UJU2 |
| Regulation Type | |
| PubMed IDs | 20011538 |
| Citations | Lu D, Liu JX, Endo T, Zhou H, Yao S, Willert K, Schmidt-Wolf IG, Kipps TJ, Carson DA: Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta-catenin pathway. PLoS One. 2009 Dec 14;4(12):e8294. doi: 10.1371/journal.pone.0008294. |
| Groups | Approved; Investigational |
| Direct Classification | Chlorophenoxyacetates |
| SMILES | CCC(=C)C(=O)C1=C(Cl)C(Cl)=C(OCC(O)=O)C=C1 |
| Pathways | Ethacrynic Acid Action Pathway |
| PharmGKB | PA449518 |
| ChEMBL | CHEMBL456 |
