| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20066351 | HPV | ENSG00000078018.22 | protein_coding | MAP2 | No | No | 4133 | A0A024R3Z1 P11137 Q6NYC5 |
| TVIS20031673 | HPV | ENSG00000078018.22 | protein_coding | MAP2 | No | No | 4133 | A0A024R3Z1 P11137 Q6NYC5 |
| TVIS20042565 | HPV | ENSG00000078018.22 | protein_coding | MAP2 | No | No | 4133 | A0A024R3Z1 P11137 Q6NYC5 |
| TVIS20054212 | HPV | ENSG00000078018.22 | protein_coding | MAP2 | No | No | 4133 | A0A024R3Z1 P11137 Q6NYC5 |
| TVIS44034524 | HTLV-1 | ENSG00000078018.22 | protein_coding | MAP2 | No | No | 4133 | A0A024R3Z1 P11137 Q6NYC5 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | MAP2 |
|---|---|
| DrugBank ID | DB01196 |
| Drug Name | Estramustine |
| Target ID | BE0001100 |
| UniProt ID | P11137 |
| Regulation Type | antagonist |
| PubMed IDs | 1599956; 1647395; 1908244; 2125244; 2679799; 6364362 |
| Citations | Moraga D, Rivas-Berrios A, Farias G, Wallin M, Maccioni RB: Estramustine-phosphate binds to a tubulin binding domain on microtubule-associated proteins MAP-2 and tau. Biochim Biophys Acta. 1992 May 22;1121(1-2):97-103.@@Stearns ME, Wang M, Sousa O: Evidence that estramustine binds MAP-1A to inhibit type IV collagenase secretion. J Cell Sci. 1991 Jan;98 ( Pt 1):55-63.@@Friden B, Rutberg M, Deinum J, Wallin M: The effect of estramustine derivatives on microtubule assembly in vitro depends on the charge of the substituent. Biochem Pharmacol. 1991 Aug 8;42(5):997-1006.@@Burns RG: Stoichiometry of estramustine phosphate binding to MAP2 measured by the disassembly of chick brain MAP2:tubulin microtubules. Cell Motil Cytoskeleton. 1990;17(3):167-73.@@Falconer MM, Vielkind U, Brown DL: Association of acetylated microtubules, vimentin intermediate filaments, and MAP 2 during early neural differentiation in EC cell culture. Biochem Cell Biol. 1989 Sep;67(9):537-44.@@Tew KD: The mechanism of action of estramustine. Semin Oncol. 1983 Sep;10(3 Suppl 3):21-6. |
| Groups | Approved; Investigational |
| Direct Classification | Estrane steroids |
| SMILES | [H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])C3=CC=C(OC(=O)N(CCCl)CCCl)C=C3CC[C@@]21[H] |
| Pathways | |
| PharmGKB | PA449507 |
| ChEMBL | CHEMBL1575 |
