| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44005531 | HTLV-1 | ENSG00000087245.13 | protein_coding | MMP2 | No | No | 4313 | P08253 |
| TVIS44036049 | HTLV-1 | ENSG00000087245.13 | protein_coding | MMP2 | No | No | 4313 | P08253 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | MMP2 |
|---|---|
| DrugBank ID | DB00786 |
| Drug Name | Marimastat |
| Target ID | BE0000642 |
| UniProt ID | P08253 |
| Regulation Type | inhibitor |
| PubMed IDs | 11752352; 10460642; 15056115; 11790786; 12527923; 15748894 |
| Citations | Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Treharne GD, Boyle JR, Goodall S, Loftus IM, Bell PR, Thompson MM: Marimastat inhibits elastin degradation and matrix metalloproteinase 2 activity in a model of aneurysm disease. Br J Surg. 1999 Aug;86(8):1053-8.@@Fanchon S, Bourd K, Septier D, Everts V, Beertsen W, Menashi S, Goldberg M: Involvement of matrix metalloproteinases in the onset of dentin mineralization. Eur J Oral Sci. 2004 Apr;112(2):171-6.@@Bernardo MM, Brown S, Li ZH, Fridman R, Mobashery S: Design, synthesis, and characterization of potent, slow-binding inhibitors that are selective for gelatinases. J Biol Chem. 2002 Mar 29;277(13):11201-7. Epub 2002 Jan 14.@@Shinoda K, Shibuya M, Hibino S, Ono Y, Matsuda K, Takemura A, Zou D, Kokubo Y, Takechi A, Kudoh S: A novel matrix metalloproteinase inhibitor, FYK-1388 suppresses tumor growth, metastasis and angiogenesis by human fibrosarcoma cell line. Int J Oncol. 2003 Feb;22(2):281-8.@@Bourd-Boittin K, Fridman R, Fanchon S, Septier D, Goldberg M, Menashi S: Matrix metalloproteinase inhibition impairs the processing, formation and mineralization of dental tissues during mouse molar development. Exp Cell Res. 2005 Apr 1;304(2):493-505. Epub 2005 Jan 11. |
| Groups | Investigational |
| Direct Classification | Secondary alcohols |
| SMILES | CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO)C(C)(C)C |
| Pathways | |
| PharmGKB | PA164748329 |
| ChEMBL | CHEMBL279785 |
