| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30007843 | HIV | ENSG00000128655.19 | protein_coding | PDE11A | No | No | 50940 | Q9HCR9 |
| TVIS30051852 | HIV | ENSG00000128655.19 | protein_coding | PDE11A | No | No | 50940 | Q9HCR9 |
| TVIS30051853 | HIV | ENSG00000128655.19 | protein_coding | PDE11A | No | No | 50940 | Q9HCR9 |
| TVIS30051854 | HIV | ENSG00000128655.19 | protein_coding | PDE11A | No | No | 50940 | Q9HCR9 |
| TVIS30051855 | HIV | ENSG00000128655.19 | protein_coding | PDE11A | No | No | 50940 | Q9HCR9 |
| TVIS30051856 | HIV | ENSG00000128655.19 | protein_coding | PDE11A | No | No | 50940 | Q9HCR9 |
| TVIS30051857 | HIV | ENSG00000128655.19 | protein_coding | PDE11A | No | No | 50940 | Q9HCR9 |
| TVIS30051858 | HIV | ENSG00000128655.19 | protein_coding | PDE11A | No | No | 50940 | Q9HCR9 |
| TVIS30051859 | HIV | ENSG00000128655.19 | protein_coding | PDE11A | No | No | 50940 | Q9HCR9 |
| TVIS20006179 | HPV | ENSG00000128655.19 | protein_coding | PDE11A | No | No | 50940 | Q9HCR9 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PDE11A |
|---|---|
| DrugBank ID | DB00820 |
| Drug Name | Tadalafil |
| Target ID | BE0003558 |
| UniProt ID | Q9HCR9 |
| Regulation Type | inhibitor |
| PubMed IDs | 19641165; 17696499; 29667180 |
| Citations | Weeks JL 2nd, Corbin JD, Francis SH: Interactions between cyclic nucleotide phosphodiesterase 11 catalytic site and substrates or tadalafil and role of a critical Gln-869 hydrogen bond. J Pharmacol Exp Ther. 2009 Oct;331(1):133-41. doi: 10.1124/jpet.109.156935. Epub 2009 Jul 29.@@Weeks JL 2nd, Zoraghi R, Francis SH, Corbin JD: N-Terminal domain of phosphodiesterase-11A4 (PDE11A4) decreases affinity of the catalytic site for substrates and tadalafil, and is involved in oligomerization. Biochemistry. 2007 Sep 11;46(36):10353-64. Epub 2007 Aug 16.@@Andersson KE: PDE5 inhibitors - pharmacology and clinical applications 20 years after sildenafil discovery. Br J Pharmacol. 2018 Jul;175(13):2554-2565. doi: 10.1111/bph.14205. Epub 2018 Apr 25. |
| Groups | Approved; Investigational |
| Direct Classification | Beta carbolines |
| SMILES | [H][C@]12CC3=C(NC4=CC=CC=C34)[C@H](N1C(=O)CN(C)C2=O)C1=CC2=C(OCO2)C=C1 |
| Pathways | |
| PharmGKB | PA10333 |
| ChEMBL | CHEMBL779 |
