| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20020075 | HPV | ENSG00000184381.20 | protein_coding | PLA2G6 | No | No | 8398 | O60733 |
| TVIS44018377 | HTLV-1 | ENSG00000184381.20 | protein_coding | PLA2G6 | No | No | 8398 | O60733 |
| TVIS44027922 | HTLV-1 | ENSG00000184381.20 | protein_coding | PLA2G6 | No | No | 8398 | O60733 |
| TVIS44048265 | HTLV-1 | ENSG00000184381.20 | protein_coding | PLA2G6 | No | No | 8398 | O60733 |
| TVIS44048264 | HTLV-1 | ENSG00000184381.20 | protein_coding | PLA2G6 | No | No | 8398 | O60733 |
| TVIS44048263 | HTLV-1 | ENSG00000184381.20 | protein_coding | PLA2G6 | No | No | 8398 | O60733 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PLA2G6 |
|---|---|
| DrugBank ID | DB01103 |
| Drug Name | Quinacrine |
| Target ID | BE0001077 |
| UniProt ID | O60733 |
| Regulation Type | inhibitor |
| PubMed IDs | 10199854; 10229494; 10449625; 10653606; 11455568 |
| Citations | Nuttle LC, Ligon AL, Farrell KR, Hester RL: Inhibition of phospholipase A2 attenuates functional hyperemia in the hamster cremaster muscle. Am J Physiol. 1999 Apr;276(4 Pt 2):H1289-94.@@Sastry BV, Hemontolor ME, Vidaver PS, Sastry WS, Janson VE: Influence of halothane on phospholipase A2 and enzymatic methylations in the rat retinal membranes. J Ocul Pharmacol Ther. 1999 Apr;15(2):165-78.@@Lohmann CH, Sagun R Jr, Sylvia VL, Cochran DL, Dean DD, Boyan BD, Schwartz Z: Surface roughness modulates the response of MG63 osteoblast-like cells to 1,25-(OH)(2)D(3) through regulation of phospholipase A(2) activity and activation of protein kinase A. J Biomed Mater Res. 1999 Nov;47(2):139-51.@@Schwartz Z, Sylvia VL, Del Toro F, Hardin RR, Dean DD, Boyan BD: 24R,25-(OH)(2)D(3) mediates its membrane receptor-dependent effects on protein kinase C and alkaline phosphatase via phospholipase A(2) and cyclooxygenase-1 but not cyclooxygenase-2 in growth plate chondrocytes. J Cell Physiol. 2000 Mar;182(3):390-401.@@Sylvia VL, Del Toro F, Dean DD, Hardin RR, Schwartz Z, Boyan BD: Effects of 1alpha,25-(OH)(2)D(3) on rat growth zone chondrocytes are mediated via cyclooxygenase-1 and phospholipase A(2). J Cell Biochem Suppl. 2001;Suppl 36:32-45. |
| Groups | Investigational |
| Direct Classification | Acridines |
| SMILES | CCN(CC)CCCC(C)NC1=C2C=C(OC)C=CC2=NC2=C1C=CC(Cl)=C2 |
| Pathways | |
| PharmGKB | PA164745551 |
| ChEMBL | CHEMBL7568 |
