| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20070157 | HPV | ENSG00000101868.13 | protein_coding | POLA1 | No | No | 5422 | A6NMQ1 P09884 |
| TVIS44031567 | HTLV-1 | ENSG00000101868.13 | protein_coding | POLA1 | No | No | 5422 | A6NMQ1 P09884 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | POLA1 |
|---|---|
| DrugBank ID | DB00242 |
| Drug Name | Cladribine |
| Target ID | BE0000546 |
| UniProt ID | P09884 |
| Regulation Type | inhibitor |
| PubMed IDs | 19576186; 16316309; 9923554; 14722255 |
| Citations | Zhenchuk A, Lotfi K, Juliusson G, Albertioni F: Mechanisms of anti-cancer action and pharmacology of clofarabine. Biochem Pharmacol. 2009 Dec 1;78(11):1351-9. doi: 10.1016/j.bcp.2009.06.094. Epub 2009 Jul 1.@@Kline JP, Larson RA: Clofarabine in the treatment of acute myeloid leukaemia and acute lymphoblastic leukaemia: a review. Expert Opin Pharmacother. 2005 Dec;6(15):2711-8.@@Takahashi T, Kanazawa J, Akinaga S, Tamaoki T, Okabe M: Antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) adenine, a novel deoxyadenosine analog, against human colon tumor xenografts by oral administration. Cancer Chemother Pharmacol. 1999;43(3):233-40.@@Hartman WR, Hentosh P: The antileukemia drug 2-chloro-2'-deoxyadenosine: an intrinsic transcriptional antagonist. Mol Pharmacol. 2004 Jan;65(1):227-34. |
| Groups | Approved; Investigational |
| Direct Classification | Purine 2'-deoxyribonucleosides |
| SMILES | NC1=C2N=CN([C@H]3C[C@H](O)[C@@H](CO)O3)C2=NC(Cl)=N1 |
| Pathways | |
| PharmGKB | PA449027 |
| ChEMBL | CHEMBL1619 |
