| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10025675 | HBV | ENSG00000120899.18 | protein_coding | PTK2B | No | No | 2185 | Q14289 |
| TVIS10044656 | HBV | ENSG00000120899.18 | protein_coding | PTK2B | No | No | 2185 | Q14289 |
| TVIS10044657 | HBV | ENSG00000120899.18 | protein_coding | PTK2B | No | No | 2185 | Q14289 |
| TVIS10051369 | HBV | ENSG00000120899.18 | protein_coding | PTK2B | No | No | 2185 | Q14289 |
| TVIS10043274 | HBV | ENSG00000120899.18 | protein_coding | PTK2B | No | No | 2185 | Q14289 |
| TVIS30009506 | HIV | ENSG00000120899.18 | protein_coding | PTK2B | No | No | 2185 | Q14289 |
| TVIS30009507 | HIV | ENSG00000120899.18 | protein_coding | PTK2B | No | No | 2185 | Q14289 |
| TVIS30083160 | HIV | ENSG00000120899.18 | protein_coding | PTK2B | No | No | 2185 | Q14289 |
| TVIS30018161 | HIV | ENSG00000120899.18 | protein_coding | PTK2B | No | No | 2185 | Q14289 |
| TVIS30068681 | HIV | ENSG00000120899.18 | protein_coding | PTK2B | No | No | 2185 | Q14289 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PTK2B |
|---|---|
| DrugBank ID | DB01097 |
| Drug Name | Leflunomide |
| Target ID | BE0000871 |
| UniProt ID | Q14289 |
| Regulation Type | antagonist |
| PubMed IDs | 19149483; 17604599; 17103252 |
| Citations | Pytel D, Sliwinski T, Poplawski T, Ferriola D, Majsterek I: Tyrosine kinase blockers: new hope for successful cancer therapy. Anticancer Agents Med Chem. 2009 Jan;9(1):66-76.@@Fukushima R, Kanamori S, Hirashiba M, Hishikawa A, Muranaka RI, Kaneto M, Nakamura K, Kato I: Teratogenicity study of the dihydroorotate-dehydrogenase inhibitor and protein tyrosine kinase inhibitor Leflunomide in mice. Reprod Toxicol. 2007 Nov-Dec;24(3-4):310-6. Epub 2007 May 18.@@Steeghs N, Nortier JW, Gelderblom H: Small molecule tyrosine kinase inhibitors in the treatment of solid tumors: an update of recent developments. Ann Surg Oncol. 2007 Feb;14(2):942-53. Epub 2006 Nov 14. |
| Groups | Approved; Investigational |
| Direct Classification | Aromatic anilides |
| SMILES | CC1=C(C=NO1)C(=O)NC1=CC=C(C=C1)C(F)(F)F |
| Pathways | |
| PharmGKB | PA450192 |
| ChEMBL | CHEMBL960 |
