| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44047401 | HTLV-1 | ENSG00000070915.10 | protein_coding | SLC12A3 | No | No | 6559 | J3QSS1 P55017 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SLC12A3 |
|---|---|
| DrugBank ID | DB00436 |
| Drug Name | Bendroflumethiazide |
| Target ID | BE0000419 |
| UniProt ID | P55017 |
| Regulation Type | inhibitor |
| PubMed IDs | 11752352; 10894798; 18216144 |
| Citations | Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Monroy A, Plata C, Hebert SC, Gamba G: Characterization of the thiazide-sensitive Na(+)-Cl(-) cotransporter: a new model for ions and diuretics interaction. Am J Physiol Renal Physiol. 2000 Jul;279(1):F161-9.@@Vallon V, Rieg T, Ahn SY, Wu W, Eraly SA, Nigam SK: Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics. Am J Physiol Renal Physiol. 2008 Apr;294(4):F867-73. doi: 10.1152/ajprenal.00528.2007. Epub 2008 Jan 23. |
| Groups | Approved |
| Direct Classification | 1,2,4-benzothiadiazine-1,1-dioxides |
| SMILES | NS(=O)(=O)C1=CC2=C(NC(CC3=CC=CC=C3)NS2(=O)=O)C=C1C(F)(F)F |
| Pathways | Bendroflumethiazide Action Pathway |
| PharmGKB | PA448563 |
| ChEMBL | CHEMBL1684 |
