| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20036373 | HPV | ENSG00000115840.14 | protein_coding | SLC25A12 | No | No | 8604 | O75746 |
| TVIS20032674 | HPV | ENSG00000115840.14 | protein_coding | SLC25A12 | No | No | 8604 | O75746 |
| TVIS20054849 | HPV | ENSG00000115840.14 | protein_coding | SLC25A12 | No | No | 8604 | O75746 |
| TVIS20054340 | HPV | ENSG00000115840.14 | protein_coding | SLC25A12 | No | No | 8604 | O75746 |
| TVIS44037960 | HTLV-1 | ENSG00000115840.14 | protein_coding | SLC25A12 | No | No | 8604 | O75746 |
| TVIS44037708 | HTLV-1 | ENSG00000115840.14 | protein_coding | SLC25A12 | No | No | 8604 | O75746 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SLC25A12 |
|---|---|
| DrugBank ID | DB00128 |
| Drug Name | Aspartic acid |
| Target ID | BE0000235 |
| UniProt ID | O75746 |
| Regulation Type | |
| PubMed IDs | 17151801; 17213189; 17497669; 17237342 |
| Citations | Correia C, Coutinho AM, Diogo L, Grazina M, Marques C, Miguel T, Ataide A, Almeida J, Borges L, Oliveira C, Oliveira G, Vicente AM: Brief report: High frequency of biochemical markers for mitochondrial dysfunction in autism: no association with the mitochondrial aspartate/glutamate carrier SLC25A12 gene. J Autism Dev Disord. 2006 Nov;36(8):1137-40.@@Contreras L, Gomez-Puertas P, Iijima M, Kobayashi K, Saheki T, Satrustegui J: Ca2+ Activation kinetics of the two aspartate-glutamate mitochondrial carriers, aralar and citrin: role in the heart malate-aspartate NADH shuttle. J Biol Chem. 2007 Mar 9;282(10):7098-106. Epub 2007 Jan 9.@@Satrustegui J, Contreras L, Ramos M, Marmol P, del Arco A, Saheki T, Pardo B: Role of aralar, the mitochondrial transporter of aspartate-glutamate, in brain N-acetylaspartate formation and Ca(2+) signaling in neuronal mitochondria. J Neurosci Res. 2007 Nov 15;85(15):3359-66.@@Satrustegui J, Pardo B, Del Arco A: Mitochondrial transporters as novel targets for intracellular calcium signaling. Physiol Rev. 2007 Jan;87(1):29-67. |
| Groups | Approved; Nutraceutical |
| Direct Classification | Aspartic acid and derivatives |
| SMILES | N[C@@H](CC(O)=O)C(O)=O |
| Pathways | Lesch-Nyhan Syndrome (LNS); Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency); Xanthinuria Type I; Hyperornithinemia with Gyrate Atrophy (HOGA); Purine Nucleoside Phosphorylase Deficiency; Carnosinuria, Carnosinemia; Tyrosine Metabolism; Disulfiram Action Pathway; Hyperprolinemia Type II; Glutamate Metabolism; Adenine Phosphoribosyltransferase Deficiency (APRT); Mercaptopurine Action Pathway; Argininosuccinic Aciduria; L-Arginine:Glycine Amidinotransferase Deficiency; Xanthine Dehydrogenase Deficiency (Xanthinuria); Tyrosinemia Type I; Hyperinsulinism-Hyperammonemia Syndrome; Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency); Mitochondrial DNA Depletion Syndrome; Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency; Carbamoyl Phosphate Synthetase Deficiency; Hyperprolinemia Type I; Myoadenylate Deaminase Deficiency; Homocarnosinosis; Malate-Aspartate Shuttle; Arginine and Proline Metabolism; Purine Metabolism; Gout or Kelley-Seegmiller Syndrome; Adenylosuccinate Lyase Deficiency; Ammonia Recycling |
| PharmGKB | PA448494 |
| ChEMBL | CHEMBL274323 |
