| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44038082 | HTLV-1 | ENSG00000151090.20 | protein_coding | THRB | No | No | 7068 | P10828 |
| TVIS44038253 | HTLV-1 | ENSG00000151090.20 | protein_coding | THRB | No | No | 7068 | P10828 |
| TVIS44044652 | HTLV-1 | ENSG00000151090.20 | protein_coding | THRB | No | No | 7068 | P10828 |
| TVIS44038130 | HTLV-1 | ENSG00000151090.20 | protein_coding | THRB | No | No | 7068 | P10828 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | THRB |
|---|---|
| DrugBank ID | DB00279 |
| Drug Name | Liothyronine |
| Target ID | BE0000315 |
| UniProt ID | P10828 |
| Regulation Type | agonist |
| PubMed IDs | 17315033; 12668276; 17016423; 17139284; 12776178; 10592235; 16099238; 11159893 |
| Citations | Bernal J: Thyroid hormone receptors in brain development and function. Nat Clin Pract Endocrinol Metab. 2007 Mar;3(3):249-59.@@Gonzalez-Sancho JM, Garcia V, Bonilla F, Munoz A: Thyroid hormone receptors/THR genes in human cancer. Cancer Lett. 2003 Mar 31;192(2):121-32.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Yen PM, Feng X, Flamant F, Chen Y, Walker RL, Weiss RE, Chassande O, Samarut J, Refetoff S, Meltzer PS: Effects of ligand and thyroid hormone receptor isoforms on hepatic gene expression profiles of thyroid hormone receptor knockout mice. EMBO Rep. 2003 Jun;4(6):581-7.@@Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.@@Wu SY, Sadow PM, Refetoff S, Weiss RE: Tissue responses to thyroid hormone in a kindred with resistance to thyroid hormone harboring a commonly occurring mutation in the thyroid hormone receptor beta gene (P453T). J Lab Clin Med. 2005 Aug;146(2):85-94.@@Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. |
| Groups | Approved; Vet_approved |
| Direct Classification | Phenylalanine and derivatives |
| SMILES | N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C=C2)C(I)=C1)C(O)=O |
| Pathways | Thyroid Hormone Synthesis |
| PharmGKB | PA164778866 |
| ChEMBL | CHEMBL1544 |
