| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20040741 | HPV | ENSG00000139287.13 | protein_coding | TPH2 | No | No | 121278 | Q8IWU9 |
| TVIS20047075 | HPV | ENSG00000139287.13 | protein_coding | TPH2 | No | No | 121278 | Q8IWU9 |
| TVIS20065360 | HPV | ENSG00000139287.13 | protein_coding | TPH2 | No | No | 121278 | Q8IWU9 |
| TVIS20039016 | HPV | ENSG00000139287.13 | protein_coding | TPH2 | No | No | 121278 | Q8IWU9 |
| TVIS44030112 | HTLV-1 | ENSG00000139287.13 | protein_coding | TPH2 | No | No | 121278 | Q8IWU9 |
| TVIS44001828 | HTLV-1 | ENSG00000139287.13 | protein_coding | TPH2 | No | No | 121278 | Q8IWU9 |
| TVIS44002170 | HTLV-1 | ENSG00000139287.13 | protein_coding | TPH2 | No | No | 121278 | Q8IWU9 |
| TVIS44017525 | HTLV-1 | ENSG00000139287.13 | protein_coding | TPH2 | No | No | 121278 | Q8IWU9 |
| TVIS44034692 | HTLV-1 | ENSG00000139287.13 | protein_coding | TPH2 | No | No | 121278 | Q8IWU9 |
| TVIS44046791 | HTLV-1 | ENSG00000139287.13 | protein_coding | TPH2 | No | No | 121278 | Q8IWU9 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | TPH2 |
|---|---|
| DrugBank ID | DB12095 |
| Drug Name | Telotristat ethyl |
| Target ID | BE0000080 |
| UniProt ID | Q8IWU9 |
| Regulation Type | antagonist |
| PubMed IDs | 25012985 |
| Citations | Kulke MH, O'Dorisio T, Phan A, Bergsland E, Law L, Banks P, Freiman J, Frazier K, Jackson J, Yao JC, Kvols L, Lapuerta P, Zambrowicz B, Fleming D, Sands A: Telotristat etiprate, a novel serotonin synthesis inhibitor, in patients with carcinoid syndrome and diarrhea not adequately controlled by octreotide. Endocr Relat Cancer. 2014 Oct;21(5):705-14. doi: 10.1530/ERC-14-0173. Epub 2014 Jul 10. |
| Groups | Approved; Investigational |
| Direct Classification | Phenylalanine and derivatives |
| SMILES | CCOC(=O)[C@@H](N)CC1=CC=C(C=C1)C1=NC(N)=NC(O[C@H](C2=CC=C(Cl)C=C2N2C=CC(C)=N2)C(F)(F)F)=C1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL2105695 |
