| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44025854 | HTLV-1 | ENSG00000196511.15 | protein_coding | TPK1 | No | No | 27010 | A0A090N8Y0 F5GZG6 Q9H3S4 |
| TVIS44025855 | HTLV-1 | ENSG00000196511.15 | protein_coding | TPK1 | No | No | 27010 | A0A090N8Y0 F5GZG6 Q9H3S4 |
| TVIS44049063 | HTLV-1 | ENSG00000196511.15 | protein_coding | TPK1 | No | No | 27010 | A0A090N8Y0 F5GZG6 Q9H3S4 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | TPK1 |
|---|---|
| DrugBank ID | DB00152 |
| Drug Name | Thiamine |
| Target ID | BE0000157 |
| UniProt ID | Q9H3S4 |
| Regulation Type | substrate |
| PubMed IDs | 11642045; 15150256; 15664409; 15514058 |
| Citations | Pylypchuk SIu, Parkhomenko IuM, Protasova ZS, Vovk AI, Donchenko HV: [Interaction of rat brain thiamine kinase with thiamine and its derivatives]. Ukr Biokhim Zh (1999). 2001 Mar-Apr;73(2):51-6.@@Melnick J, Lis E, Park JH, Kinsland C, Mori H, Baba T, Perkins J, Schyns G, Vassieva O, Osterman A, Begley TP: Identification of the two missing bacterial genes involved in thiamine salvage: thiamine pyrophosphokinase and thiamine kinase. J Bacteriol. 2004 Jun;186(11):3660-2.@@Bellyei S, Szigeti A, Boronkai A, Szabo Z, Bene J, Janaky T, Barna L, Sipos K, Minik O, Kravjak A, Ohmacht R, Melegh B, Zavodszky P, Than GN, Sumegi B, Bohn H, Than NG: Cloning, sequencing, structural and molecular biological characterization of placental protein 20 (PP20)/human thiamin pyrophosphokinase (hTPK). Placenta. 2005 Jan;26(1):34-46.@@de Jong L, Meng Y, Dent J, Hekimi S: Thiamine pyrophosphate biosynthesis and transport in the nematode Caenorhabditis elegans. Genetics. 2004 Oct;168(2):845-54. |
| Groups | Approved; Investigational; Nutraceutical; Vet_approved |
| Direct Classification | Thiamines |
| SMILES | CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N |
| Pathways | Thiamine Metabolism |
| PharmGKB | PA451652 |
| ChEMBL | CHEMBL1547 |
