| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44050012 | HTLV-1 | ENSG00000116874.12 | protein_coding | WARS2 | No | No | 10352 | Q9UGM6 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | WARS2 |
|---|---|
| DrugBank ID | DB00150 |
| Drug Name | Tryptophan |
| Target ID | BE0002311 |
| UniProt ID | Q9UGM6 |
| Regulation Type | inhibitor |
| PubMed IDs | 17114825; 17428498; 16639024; 16724112; 16636268 |
| Citations | Paley EL, Denisova G, Sokolova O, Posternak N, Wang X, Brownell AL: Tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in human cell and mouse models. Neuromolecular Med. 2007;9(1):55-82.@@Retailleau P, Weinreb V, Hu M, Carter CW Jr: Crystal structure of tryptophanyl-tRNA synthetase complexed with adenosine-5' tetraphosphate: evidence for distributed use of catalytic binding energy in amino acid activation by class I aminoacyl-tRNA synthetases. J Mol Biol. 2007 May 25;369(1):108-28. Epub 2007 Mar 12.@@Banin E, Dorrell MI, Aguilar E, Ritter MR, Aderman CM, Smith AC, Friedlander J, Friedlander M: T2-TrpRS inhibits preretinal neovascularization and enhances physiological vascular regrowth in OIR as assessed by a new method of quantification. Invest Ophthalmol Vis Sci. 2006 May;47(5):2125-34.@@Yang XL, Otero FJ, Ewalt KL, Liu J, Swairjo MA, Kohrer C, RajBhandary UL, Skene RJ, McRee DE, Schimmel P: Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis. EMBO J. 2006 Jun 21;25(12):2919-29. Epub 2006 May 25.@@Charriere F, Helgadottir S, Horn EK, Soll D, Schneider A: Dual targeting of a single tRNA(Trp) requires two different tryptophanyl-tRNA synthetases in Trypanosoma brucei. Proc Natl Acad Sci U S A. 2006 May 2;103(18):6847-52. Epub 2006 Apr 24. |
| Groups | Approved; Nutraceutical; Withdrawn |
| Direct Classification | Indolyl carboxylic acids and derivatives |
| SMILES | N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O |
| Pathways | Tryptophan Metabolism |
| PharmGKB | PA10323 |
| ChEMBL | CHEMBL54976 |
