Basic Information
VIS ID
TVIS10000004
Fusion event
HBV-chr2:q35 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2019
PubMed ID
30535432
Virus Sequence
Virus name
HBV
Reference genome
KR014001.1
Region type
S/P
Start
689
Integrated sequence
AACTGCACTTGTATTCCCATCCCATCATCTTTGGCTTTCGCAAGATTCCTATGGGAGTGGGCCTCAGTCCGTTTCTCCTGGCTCAGTTTTCTAGTGCCAT| |TTGTTCAGTGATTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAACATCTTGAGTCCCTT
Host Sequence
Chromosome
chr2
Cytoband
q35
Reference genome
GRCh37/hg19
Start
216281034/215416311 (Hg38)
End
216281034/215416311 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-10b/Upstream/1658152; hsa-mir-1244-1/Downstream/2484202;
Nearest TSS
ENST00000437798/Upstream/6361; ENST00000412951/Downstream/4959;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/103902, chr2-CpG: 43/Downstream/19233
Downstream sequence
ATAATTTTATGCATGAATTTTGGTGTTCATGTGGCTTGGA
Junction sequence
CGCAAGATTCGTATGGGAGTGGGCGTCCGTAGGATTAGCGAGGCTCAGTTTTCTATTTCCATATAATTTTATGCATGAATTTTGGTGTTCATGTGGCTTGGA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Ruan, P., et al. Different types of viralhost junction found in HBV integration breakpoints in HBVinfected patients. Mol Med Rep ,2019,19(2): 1410-1416.
Curate