Basic Information
VIS ID
TVIS10000006
Fusion event
HBV-chr16:q12.1 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2019
PubMed ID
30535432
Virus Sequence
Virus name
HBV
Reference genome
MG571337.1
Region type
Prec
Start
1908
Integrated sequence
GCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACAT| |TGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTACTCTCTTTTTTGCCTTCTGACTTTTTTCCTTCTATTCGAGATCTCCTCGACACCGCCTCTGCT
Host Sequence
Chromosome
chr16
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
51320070/51286159 (Hg38)
End
51320070/51286159 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/543782; hsa-mir-11401/Downstream/4959361;
Nearest TSS
ENST00000527434/Upstream/39304; ENST00000642667/Downstream/70373;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/129810, chr16-CpG: 125/Downstream/1259565
Nearby gene
UNGP1(-7384) ;
Downstream sequence
CACCCAAGGCACATCTGGTGATGTGCTGTGACTCTTTGGTAATCATCCTTAGTGGGATCAGTTGGGGCTATTTCTTGCATGGCATTTGAATGAGAACTCTACCTCCAAATGGCATGATTTCCCAGGGCAT
Junction sequence
AGATCTCGAATAGAAGGAAAAAAGACAGAAGGCAAAAAAGTGAGTAACTCCACAGAAGCTCCAAATTCTTTATACGGGTCAATGTCCATGCCCCAAAGCCACCCAAGGCACATCTGGTGATGTGCTGTGACTCTTTGGTAATCATCCTTAGTGGGATCAGTTGGGGCTATTTCTTGCATGGCATTTGAATGAGAACTCTACCTCCAAATGGCATGATTTCCCAGGGCAT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Ruan, P., et al. Different types of viralhost junction found in HBV integration breakpoints in HBVinfected patients. Mol Med Rep ,2019,19(2): 1410-1416.
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