Basic Information
VIS ID
TVIS10000008
Fusion event
HBV-chr14:q11.2 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2019
PubMed ID
30535432
Virus Sequence
Virus name
HBV
Reference genome
GU815645.1
Region type
X
Start
1651
Integrated sequence
TCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACGGGAACCTGCCCAAGGTCTT| |GCATAAGAGGACTCTTGGACTTTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTGTGTTTAATGAGTGGGAGGAGTTGGGGGAGGAG
Host Sequence
Chromosome
chr14
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
19828316/19240600 (Hg38)
End
19828316/19240600 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-1185-1/Downstream/1782714;
Nearest TSS
ENST00000550708/Upstream/65070; ENST00000551932/Downstream/4362;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/107643, chr14-CpG: 23/Downstream/26447
Nearby gene
LOC100420097(-1559) ; NBEAP6(+5064) ;
Downstream sequence
GCGCACCCTGGATTCGAGCCAGGGATGACAGGGTCCCCGGGGCCCAGCGCAGGGGCTGATGAGAAGGCACTTTCGTCCGTGGGGGACCCTGGCCCTGCTTCTCTGTGGCGCGGTTTGTTTTTTTTTTTCTTTTCTGCCACAGGTGCCTTACCTCTCCTCCCTCAAACCTCA
Junction sequence
GGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACGGGAACCTGCCCAAGGACTTGCGCACCCTGGATTCGAGCCAGGGATGACAGGGTCCCCGGGGCCCAGCGCAGGGGCTGATGAGAAGGCACTTTCGTCCGTGGGGGACCCTGGCCCTGCTTCTCTGTGGCGCGGTTTGTTTTTTTTTTTCTTTTCTGCCACAGGTGCCTTACCTCTCCTCCCTCAAACCTCA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Ruan, P., et al. Different types of viralhost junction found in HBV integration breakpoints in HBVinfected patients. Mol Med Rep ,2019,19(2): 1410-1416.
Curate