Basic Information
VIS ID
TVIS10000010
Fusion event
HBV-chr14:q22.3 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2019
PubMed ID
30535432
Virus Sequence
Virus name
HBV
Subtype
B2
Reference genome
JQ688405
Region type
X
Start
1831
Integrated sequence
GGGAGGAGTTGGGGGAGGAGGTTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTGTGTTCACCAGCACCATGCAACTTTTTCACCTC| |TGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAG
Host Sequence
Chromosome
chr14
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
57417636/56950918 (Hg38)
End
57417636/56950918 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-208a/Upstream/2072725; hsa-mir-1185-1/Downstream/2696044;
Nearest TSS
ENST00000550708/Upstream/57208; ENST00000554213/Downstream/117624;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/133078, chr14-CpG: 57/Downstream/317470
Nearby gene
LOC110121324(+1372) ;
Downstream sequence
TTTGCTGTCTTGGGCAGTCCTTAATTTTAGTTCATTTTCCTGTACCTATTTATTTGATAGCTCATTAATTGCCTCAGAGCAGATA
Junction sequence
AGACTCTAAGGCCTCCCGATACAGAGCAGAGGCGGTGTCGAGGAGATCTCGAATAGAAGGAAAGAAGTCAGAAGGCAAAAAAGAGAGTAACTCCACAGAAGCTCCAAATTCTTTATACGGGTCAATGTCCATGCCCCAAAGCCACCCAAGGCACAGCTTGGAGGCTTGAACAGTAGGACATGAACATGAGATGATTAGGCAGAGTTTGCTGTCTTGGGCAGTCCTTAATTTTAGTTCATTTTCCTGTACCTATTTATTTGATAGCTCATTAATTGCCTCAGAGCAGATA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Ruan, P., et al. Different types of viralhost junction found in HBV integration breakpoints in HBVinfected patients. Mol Med Rep ,2019,19(2): 1410-1416.
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