Basic Information
VIS ID
TVIS10000011
Fusion event
HBV-chr16:p11.1 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2019
PubMed ID
30535432
Virus Sequence
Virus name
HBV
Reference genome
JX026886.1
Region type
X
Start
1760
Integrated sequence
GACTCTTGGACTTTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTGTGTTTACTGAGTGGGAGGAGTTGGGGGAGGAGATTAGGTTG| |AAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTGTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTAC
Host Sequence
Chromosome
chr16
Cytoband
p11.1
Reference genome
GRCh37/hg19
Start
34990970/35756599 (Hg38)
End
34990970/35756599 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/1592926; hsa-mir-11401/Downstream/14536017;
Nearest TSS
ENST00000527434/Upstream/8242; ENST00000569239/Downstream/30288;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/181096, chr16-CpG: 158/Downstream/344552
Nearby gene
RNA5SP412(-1314) ;
Downstream sequence
TGAATAAAAAGAAAAGTTTAACTCTGTGAGATGAAACCACATTTGAAGAGCATTTTGACAGATTGCTTGTTTCTAGGTTGTATCATGAGATATTTGTTTCTTCACTATATTTTCAAGGGGCRCTA
Junction sequence
ATTAGGCAGAGGTGAAAAGTTGCATGGTGCTGGTGAACACACCAATTTATGCCTACAGCCTCCTAGTACAAAGACCTTCTGAATAAAAAGAAAAGTTTAACTCTGTGAGATGAAACCACATTTGAAGAGCATTTTGACAGATTGCTTGTTTCTAGGTTGTATCATGAGATATTTGTTTCTTCACTATATTTTCAAGGGGCRCTA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Ruan, P., et al. Different types of viralhost junction found in HBV integration breakpoints in HBVinfected patients. Mol Med Rep ,2019,19(2): 1410-1416.
Curate