Basic Information
VIS ID
TVIS10000012
Fusion event
HBV-chr9:q22.33 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2019
PubMed ID
30535432
Virus Sequence
Virus name
HBV
Reference genome
AB713529.1
Region type
X/P
Start
1546
Integrated sequence
CCCGCGGACGACCCCTCCCGGGGCCGCTTGGGGCTCTACCGCCCGCTTCTCCGTCTGCCGTACCGACCGACCACGGGGCGCACCTCTCTTTACGCGGGAC| |TCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCAAGGAGACCACCGTGAACGCCCATTGGAAACTGCCCCAG
Host Sequence
Chromosome
chr9
Cytoband
q22.32
Reference genome
GRCh37/hg19
Start
98928137/96165855 (Hg38)
End
98928137/96165855 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-let-7a-1/Upstream/1079761; hsa-mir-12126/Downstream/1197699;
Nearest TSS
ENST00000422679/Upstream/49444; ENST00000448857/Downstream/74049;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/137832, chr9-CpG: 20/Downstream/52356
Downstream sequence
TCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAAACCACCGTGAACGCCCACCAGGTCTTGCCCAAGGT
Junction sequence
GGCTGAGGCAGGAGAATCACTTGATCCCCAGAGGCAGAGGTGGCAATGAGGTGAGATTGTGCCACTGGACTCCAGCCTGACCTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAAACCACCGTGAACGCCCACCAGGTCTTGCCCAAGGT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Ruan, P., et al. Different types of viralhost junction found in HBV integration breakpoints in HBVinfected patients. Mol Med Rep ,2019,19(2): 1410-1416.
Curate