Basic Information
VIS ID
TVIS10000013
Fusion event
HBV-chrX:p21.1 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2019
PubMed ID
30535432
Virus Sequence
Virus name
HBV
Reference genome
MG571336.1
Region type
X/P
Start
1465
Integrated sequence
TCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCCGCGGACGACCCCTCCC| |GGGGCCGCTTGGGGCTCTACCGCCCGCTTCTCCGCCTGCTGTACCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCA
Host Sequence
Chromosome
chrX
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
36919408/36901335 (Hg38)
End
36919408/36901335 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-23c/Upstream/4259776; hsa-let-7f-2/Downstream/1122560;
Nearest TSS
ENST00000429181/Upstream/461043; ENST00000358047/Downstream/107062;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/1275135, chrX-CpG: 90/Downstream/56097
Nearby gene
LOC105373154(+1063) ;
Downstream sequence
CGCTGAATCCCGCGGACGACCCCTCCCAAATTGCTCACTACAAATATTATTTTCACCCCTGGA
Junction sequence
TTCTGTCGTGCTCTCCCGCAAGTATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCCGCGGACGACCCCTCCCAAATTGCTCACTACAAATATTATTTTCACCCCTGGA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Ruan, P., et al. Different types of viralhost junction found in HBV integration breakpoints in HBVinfected patients. Mol Med Rep ,2019,19(2): 1410-1416.
Curate