Basic Information
VIS ID
TVIS10000014
Fusion event
HBV-chr5:p13.1 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2019
PubMed ID
30535432
Virus Sequence
Virus name
HBV
Reference genome
JX507212.1
Region type
X/P
Start
1513
Integrated sequence
ACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGCGGACGACCCGTCTCGGGGCCGTTTGGGACTCTACCGTCCCCTTCTTCGTCTGCCGTTCCGGC| |CGACCACGGGGCGCACCTCTCTTTACGCGGTCTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAG
Host Sequence
Chromosome
chr5
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
42009760/42009658 (Hg38)
End
42009760/42009658 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA5A
Nearest miRNA
hsa-mir-10397/Upstream/3452097; hsa-mir-103a-1/Downstream/11941846;
Nearest TSS
ENST00000502646/Upstream/70360; ENST00000564402/Downstream/178608;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/84044, chr5-CpG: 21/Downstream/413770
Downstream sequence
GATTGCTGCACCCCACATCCACAGACTGCCTGTGC
Junction sequence
GTTTGGGACTCTACCGTCCCCTTCTTCGTCTGCCGTTCCGGCTGATTGCTGCACCCCACATCCACAGACTGCCTGTGC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Ruan, P., et al. Different types of viralhost junction found in HBV integration breakpoints in HBVinfected patients. Mol Med Rep ,2019,19(2): 1410-1416.
Curate