Basic Information
VIS ID
TVIS10000035
Fusion event
HBV-chr13 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1708
Integrated sequence
CATGGAGACCACCGTGAACGCCCACCGAATGTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCTGCAATGTCAACGACCGACCTTGAGGCATAC| |TTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCAC
Host Sequence
Chromosome
chr13
Cytoband
q13.1
Reference genome
GRCh38.p7
Start
31729164 (Hg38)
End
31729164 (Hg38)
Orient
+
Nearest miRNA
hsa-mir-2276/Upstream/7566660; hsa-mir-1267/Downstream/7934870;
Nearest TSS
ENST00000623511/Upstream/309175; ENST00000380314/Downstream/10378;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/528267, chr13-CpG: 70/Downstream/117329
Nearby gene
PRPF31(-291165) ; RXFP2(+10378) ;
Downstream sequence
TAGAATAAAATAGAAAGTACAGAAATAGAC
Junction sequence
GCAATGTCAACGACCGACCTTGAGGCATACTAGAATAAAATAGAAAGTACAGAAATAGAC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
Curate