Basic Information
VIS ID
TVIS10000045
Fusion event
HBV-chr8 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1810
Integrated sequence
CAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCA| |GCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACAT
Host Sequence
Chromosome
chr8
Cytoband
q22.1
Reference genome
GRCh38.p7
Start
93745853 (Hg38)
End
93745853 (Hg38)
Orient
+
Fragile sites / regions
FRA8B
Nearest miRNA
hsa-mir-12123/Upstream/716014; hsa-mir-10400/Downstream/170169;
Nearest TSS
ENST00000518652/Upstream/4660; ENST00000481620/Downstream/8991;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/4582, chr8-CpG: 20/Downstream/8919
Nearby gene
PRPF31(-1319) ;
Downstream sequence
GGCTGTAGGCATAAATTGGTCTGCGCACCA
Junction sequence
TAAATGATTTATGGTAAATAGAACTGAACAGGCTGTAGGCATAAATTGGTCTGCGCACCA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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