Basic Information
VIS ID
TVIS10000046
Fusion event
HBV-LINC01643 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1770
Integrated sequence
GACTCTCTGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTT| |TGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAG
Host Sequence
Chromosome
chr22
Cytoband
q12.3
Reference genome
GRCh38.p7
Start
34066380 (Hg38)
End
34066380 (Hg38)
Orient
-
Location type
Intronic
Target gene
LINC01643
Nearest miRNA
hsa-mir-1286/Upstream/629711; hsa-let-7a-3/Downstream/1269260;
Nearest TSS
ENST00000624155/Upstream/48907; ENST00000624442/Downstream/142882;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/143731, chr22-CpG: 76/Downstream/1190988
Downstream sequence
GTTGGGGGAGGAGATTAGATTAAAGGTCTT
Junction sequence
TAGTTGTGACAGAGGCAGCATGGCCCACAAGTTGGGGGAGGAGATTAGATTAAAGGTCTT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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