Basic Information
VIS ID
TVIS10000051
Fusion event
HBV-CTD integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1305
Integrated sequence
GGCTGGGGCTTGGTCATGGGCCATCAGCGCGTGCGTGGAACCTTTTCGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCCGCTTGTTTTGCTCGCA| |GCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTCTCCCGCAAATATACATCGTATCCATGGCTGCTAGGCTGTGCTGCCAACTGGAT
Host Sequence
Chromosome
chr5
Cytoband
q11.2
Reference genome
GRCh38.p7
Start
53817392 (Hg38)
End
53817392 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5H
Target gene
CTD
Nearest miRNA
hsa-mir-10397/Upstream/15259831; hsa-mir-103a-1/Downstream/134112;
Nearest TSS
ENST00000502646/Upstream/171197; ENST00000512618/Downstream/2284;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/256352, chr5-CpG: 59/Downstream/492710
Downstream sequence
CAGAACTCCTTCACGCTTGTTCTGCTCGCA
Junction sequence
ATGCTATTACTGTGGGGAATTTGACACAACCAGAACTCCTTCACGCTTGTTCTGCTCGCA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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