Basic Information
VIS ID
TVIS10000058
Fusion event
HBV-LINC02627 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1775
Integrated sequence
TCTGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTAC| |TAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCC
Host Sequence
Chromosome
chr10
Cytoband
q25.1
Reference genome
GRCh38.p7
Start
105717410 (Hg38)
End
105717410 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
LINC02627
Nearest miRNA
hsa-mir-107/Upstream/1449005; hsa-mir-202/Downstream/5180680;
Nearest TSS
ENST00000439456/Upstream/558482; ENST00000424701/Downstream/101787;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/1074356, chr10-CpG: 100/Downstream/1446612
Nearby gene
PRPF31(-91365) ;
Downstream sequence
GGGAGGAGATTAGATTAAAGGTCTTTGTAC
Junction sequence
TTTGTACAGACGGGGTTTCTCTGTGTGAGGGGAGGAGATTAGATTAAAGGTCTTTGTAC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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