LRP1B _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000061
Fusion event
HBV-LRP1B integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1829
Integrated sequence
GACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCA| |CCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTT
Host Sequence
Chromosome
chr2
Cytoband
q22.1
Reference genome
GRCh38.p7
Start
140988972 (Hg38)
End
140988972 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
LRP1B
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-200c-3p ; hsa-mir-106b-3p ; hsa-mir-5692a
Nearest miRNA
hsa-mir-128-1/Upstream/402287; hsa-mir-10b/Downstream/8341306;
Nearest TSS
ENST00000437798/Upstream/630904; ENST00000410015/Downstream/821429;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/2207892, chr2-CpG: 58/Downstream/1141183
Nearest cancer related gene
LRP1B(TSG, No orient, 0)
Downstream sequence
TCTGCGCACCAGCACCATGCAACTTTTTCA
Junction sequence
AATACACAGCTTGTGGTATAGTTTACAATGTCTGCGCACCAGCACCATGCAACTTTTTCA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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