VISDB - VIS Detail

Expression analysis of TCGA samples

Basic Information

VIS ID

TVIS10000064

Fusion event

HBV-ZFYVE9 integration

Validated

Yes

Detection method

invPCR

Data source

Curated

Sample type

Cell line

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Perfect

Reported year

2018

PubMed ID

29437961

Virus Sequence

Virus name

HBV

Reference genome

U95551.1

End

1812

Integrated sequence

AAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGC| |ACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCG

Host Sequence

Chromosome

chr1

Cytoband

p32.3

Reference genome

GRCh38.p7

Start

52219974 (Hg38)

End

52219974 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

FRA1B

Target gene

ZFYVE9

miRNAs that regulate target gene

hsa-mir-615-3p ; hsa-mir-222-3p ; hsa-mir-17-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106a-5p ; hsa-mir-130a-3p ; hsa-mir-106b-5p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-20b-5p ; hsa-mir-519c-3p ; hsa-mir-526b-3p ; hsa-mir-519b-3p ; hsa-mir-519d-3p ; hsa-mir-519a-3p ; hsa-mir-580-5p ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-1225-5p ; hsa-mir-1229-5p ; hsa-mir-4295 ; hsa-mir-4328 ; hsa-mir-3666 ; hsa-mir-5002-3p ; hsa-mir-141-5p ; hsa-mir-145-5p ; hsa-mir-5195-3p ; hsa-mir-4643 ; hsa-mir-526b-5p ; hsa-mir-591 ; hsa-mir-6758-5p ; hsa-mir-6856-5p ; hsa-mir-4684-3p ; hsa-mir-503-3p ; hsa-mir-367-5p ; hsa-mir-4796-3p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-6514-3p ; hsa-mir-7977 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-6847-3p ; hsa-mir-6811-3p ; hsa-mir-214-5p ; hsa-mir-4755-3p ; hsa-mir-4753-5p ; hsa-mir-6768-3p

Nearest miRNA

hsa-mir-12136/Upstream/383572; hsa-mir-101-1/Downstream/1834105;

Nearest TSS

ENST00000473358/Upstream/3594; ENST00000469134/Downstream/75921;

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/77142, chr1-CpG: 72/Downstream/145757

Downstream sequence

CTGTAGGCATAAATTGGTCTGCGCACCAGC

Junction sequence

CACCAGCTTGGCCAGGCTGGTCTCGAACTCCTGTAGGCATAAATTGGTCTGCGCACCAGC

* Color: Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence

Reference

Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).