Basic Information
VIS ID
TVIS10000066
Fusion event
HBV-PKN2-AS1 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1816
Integrated sequence
CTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCA| |TGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCC
Host Sequence
Chromosome
chr1
Cytoband
p22.2
Reference genome
GRCh38.p7
Start
88665227 (Hg38)
End
88665227 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1D
Target gene
PKN2-AS1
Nearest miRNA
hsa-mir-101-1/Upstream/2307540; hsa-mir-11399/Downstream/5181605;
Nearest TSS
ENST00000473358/Upstream/94367; ENST00000436111/Downstream/18995;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/202150, chr1-CpG: 106/Downstream/18705
Downstream sequence
AGGCATAAATTGGTCTGCGCACCAGCACCA
Junction sequence
ACCACCCAGAGACATACAGAGATGTAGAGGAGGCATAAATTGGTCTGCGCACCAGCACCA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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