Basic Information
VIS ID
TVIS10000067
Fusion event
HBV-chr1 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1733
Integrated sequence
CGAATGTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCTGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACT| |GGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTC
Host Sequence
Chromosome
chr1
Cytoband
p21.1
Reference genome
GRCh38.p7
Start
106305730 (Hg38)
End
106305730 (Hg38)
Orient
-
Nearest miRNA
hsa-mir-101-1/Upstream/6024422; hsa-mir-11399/Downstream/1591493;
Nearest TSS
ENST00000473358/Upstream/224569; ENST00000415910/Downstream/512509;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/224498, chr1-CpG: 104/Downstream/750853
Nearby gene
SREBF2-AS1(-221231) ; PRPF31(+512509) ;
Downstream sequence
CATACTTCAAAGACTGTTTGTTTAAAGACT
Junction sequence
TTAAATTACAGTAATTATGACACTGTACTTCATACTTCAAAGACTGTTTGTTTAAAGACT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
Curate