Basic Information
VIS ID
TVIS10000071
Fusion event
HBV-ODR4 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1824
Integrated sequence
TTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAG
Host Sequence
Chromosome
chr1
Cytoband
q31.1
Reference genome
GRCh38.p7
Start
186392640 (Hg38)
End
186392640 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1K
Target gene
ODR4
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-1-3p ; hsa-mir-3180-5p ; hsa-mir-5195-3p ; hsa-mir-145-5p ; hsa-mir-4775 ; hsa-mir-6832-5p ; hsa-mir-4735-5p ; hsa-mir-770-5p ; hsa-mir-4712-5p ; hsa-mir-936 ; hsa-mir-590-3p ; hsa-mir-4524a-3p ; hsa-mir-6758-3p ; hsa-mir-4528 ; hsa-mir-216a-5p
Nearest miRNA
hsa-mir-101-1/Upstream/5954250; hsa-mir-1182/Downstream/6323688;
Nearest TSS
ENST00000473358/Upstream/16771; ENST00000574641/Downstream/5780;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/16924, chr1-CpG: 23/Downstream/288039
Downstream sequence
ATTGGTCTGCGCACCAGCACCATGCAACTT
Junction sequence
TTCACCATGTTGACCAGGCTGGTCTCAAACATTGGTCTGCGCACCAGCACCATGCAACTT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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